We expect an effect of context, odor, and user group on reward-related brain activation
ID
Bron
Verkorte titel
Aandoening
Not applicable
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The brain response to odors in reward-related brain areas, measured with fMRI
Achtergrond van het onderzoek
Flavors play an important role in reward from food and e-cigarettes. Whereas sweet flavors are popular in both food and e-cigarettes, savory food products are popular but savory e-liquids seldom exist. Brain areas involved in reward from food and reward from smoking overlap, but more knowledge is needed about similarities and differences between reward-related brain activation in response to food versus e-cigarette cues. This study aims to investigate the role of flavors in reward-related brain activation in an e-cigarette context in comparison to a food context.
Doel van het onderzoek
We expect an effect of context, odor, and user group on reward-related brain activation
Onderzoeksopzet
Not applicable
Onderzoeksproduct en/of interventie
During fMRI, odors will be presented using an olfactometer. Accompanying visual cues will be used to create an e-cigarette and food context. Ratings for odor liking, intensity of odor sweetness, intensity of odor savoriness, and willingness to try the e-cigarette/food product will be collected on a 100-unit Visual Analogue Scale
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Light cigarette smoker or non-smoker
- Susceptible to e-cigarette use
- Normal olfactory function according to the Sniffin’ Sticks identification test
- Good proficiency of the Dutch language
- Right-handed
- Aged 18-55 years at the time of inclusion
- Normal BMI (between 18.5-25 kg/m2)
- Healthy as defined by the screening questionnaire
- Willing to comply with the study procedures
- Willing to be informed about incidental findings of pathology and approving of reporting this to their general physician
- Willing to refrain from using drugs other than tobacco and alcohol for one week before the test session
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Dislike the odors under investigation
- Allergic or hyper sensitive reaction to yoghurt
- The use of prescribed or non-prescribed medication in the month prior to the test session, other than occasional use of pain medication (such as paracetamol and NSAID’s) or oral contraceptives
- Have a history of drug or alcohol dependence
- Have a psychiatric, neurological, or eating disorder or chronic medical condition
- Be employed by the Division of Human Nutrition and Health of Wageningen University or doing an MSc internship/writing a thesis at the Sensory Science and Eating Behavior chair group within the Division of Human Nutrition and Health of Wageningen University
- Participation in another medical-scientific study (except for EetMeetWeet)
- Claustrophobic (self-report)
- Having a contra-indication to MRI scanning (including, but not limited to): pacemakers and defibrillators, epilepsy or family history of epilepsy, intraorbital or intraocular metallic fragments, ferromagnetic implants, presence of non-removable piercings.
- Limited sight that is not corrected with contact lenses or cannot be corrected with our MRI safe glasses (maximum strength is +6 and -6)
- For women: lactating, being pregnant, or using a IUD as anti-conceptive (with exception of the Mirena IUD, which is MRI safe).
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| Register | ID |
|---|---|
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| Ander register | METC WUR : METC 19/19 |