The Goodpasture antigen binding protein is able to modify the activation of the immune response, therefore influencing the pathology of autoimmune diseases.
ID
Bron
Aandoening
autoimmunity GPBP leukocytes
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
The expression of GPBP on different subsets of leukocytes will be determined with flow cytometric analyses. With these experiments, we are able to describe which specific leukocytes express GPBP. Moreover, since we will analyse both autoimmune and healthy subjects, differences between GPBP expression on particular cell subsets in changing inflammatory conditions might be discovered.
Achtergrond van het onderzoek
The Goodpasture antigen binding protein (GPBP) is a protein kinase that binds and phosphorylates collagen. Increased GPBP expression has been found in different autoimmune diseases. However, the cells that produce this GPBP are not known yet. Moreover, the exact function of the protein in the immune response is also not known. Our preliminary results indicate that GPBP is able to interact with proteins of the innate immune system and that it is expressed on leukocytes involved in the innate immune response. The aim of this study is to isolate leukocytes from both patients with an autoimmune disease and healthy controls in order to determine expression levels and functions of GPBP in these cells.
Doel van het onderzoek
The Goodpasture antigen binding protein is able to modify the activation of the immune response, therefore influencing the pathology of autoimmune diseases.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
N/A
Publiek
Pilar Martinez
Maastricht 6229 ER
The Netherlands
+31 (0)43 3881042
p.martinez@maastrichtuniversity.nl
Wetenschappelijk
Pilar Martinez
Maastricht 6229 ER
The Netherlands
+31 (0)43 3881042
p.martinez@maastrichtuniversity.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Autoimmune patients:
1. 18 - 50 years old;
2. Diagnosed with myasthenia gravis or multiple sclerosis.
Healthy controls:
1. 18 – 50 years old.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Minors or incapacitated adults will not be included in the study. Subjects that do not want to give their informed consent will not be included.
Healthy controls that have had previous immune-related diseases (e.g chronic inflammatory reactions, autoimmune disease, immunosuppressive treatment, …) will be excluded from this study, since the inflammatory response of these patients can be disturbed.
Opzet
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| Register | ID |
|---|---|
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| OMON | NL-OMON34337 |