Mitochondrial oxygenation and consumption are altered in the affected extremity of patients with CRPS.
ID
Bron
Verkorte titel
Aandoening
Complex Regional Pain Syndrome
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
MitoPO2 and mitoVO2
Achtergrond van het onderzoek
Complex regional pain syndrome (CRPS) is a complication after trauma or surgery. CRPS is characterized by chronic pain in a distal extremity, usually combined with abnormal sensory, autonomic, motor and/or trophic changes. Temperature asymmetry is common in CRPS. The pathophysiology of vasomotor disturbances in CRPS is still not completely understood. Endothelial dysfunction is one of the underlying mechanisms of vasomotor disturbances in CRPS. Mitochondrial dysfunction is associated with endothelial dysfunction in cardiovascular diseases. It could be possible that mitochondrial dysfunction also plays a role in the pathogenesis of vasomotor disturbances CRPS. The COMET monitor assesses Cellular Oxygen METabolism by measuring cutaneous mitoPO2 and mitoVO2 in humans.
The primary objective is to investigate if there is altered mitochondrial oxygenation and consumption in the skin cells of the affected extremity in patients with CRPS by measuring the mitoPO2 and mitoVO2.
Doel van het onderzoek
Mitochondrial oxygenation and consumption are altered in the affected extremity of patients with CRPS.
Onderzoeksopzet
Single measurement
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients with CRPS
• Diagnosed with CRPS according to the new IASP criteria. We will only include patients that still meet these criteria.
• Clinically the contralateral extremity must be without signs or symptoms in a way that it can be used as a control
• Signed informed consent
Healthy controls
• Signed informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Patients with CRPS
• < 18 years of age
• Presence of mitochondrial disease
• Porphyria
Healthy controls
• < 18 years of age
• Presence of mitochondrial disease
• Porphyria
• (Consideration of) diagnosis of CRPS in history
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL8341 |
| CCMO | NL68803.078.19 |