The overall hypothesis of this study is that exposures in early life (fetal period and early childhood) are associated with health outcomes in later life.
Bron
Verkorte titel
Aandoening
The study focuses on six primary research areas: (1) maternal health, (2) growth and physical development, (3) behaviour and cognitive development, (4) asthma and allergy, (5) diseases in childhood and (6) health care.
Ondersteuning
Organization for Health Research and Development (ZonMw) and the Ministry of Health, Welfare and Sport.
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
The study focuses on six primary research areas: (1) maternal health, (2) growth and physical development, (3) behaviour and cognitive development, (4) asthma and allergy, (5) diseases in childhood and (6) health care.
Achtergrond van het onderzoek
The Generation R Study is a population-based prospective cohort study from fetal life until adulthood. The study is designed to identify early environmental and genetic causes and causal pathways leading to normal and abnormal growth, development and health from fetal life, childhood and young adulthood. This multidisciplinary study focuses on several health outcomes including behaviour and cognition, body composition, eye development, growth, hearing, heart and vascular development, infectious disease and immunity, oral health and facial growth, respiratory health, allergy and skin disorders of children and their parents. Main exposures of interest include environmental, endocrine, genomic (genetic, epigenetic, microbiome), lifestyle related, nutritional and socio-demographic determinants. In total, 9,778 mothers with a delivery date from April 2002 until January 2006 were enrolled in the study. Response at baseline was 61%, and general follow-up rates until the age of 10 years were around 80%. Data collection in children and their parents includes questionnaires, interviews, detailed physical and ultrasound examinations, behavioural observations, lung function, Magnetic Resonance Imaging (MRI) and biological sampling. Genome and epigenome wide association screens are available. Eventually, results from the Generation R Study contribute to the development of strategies for optimizing health and healthcare for pregnant women and children.
Doel van het onderzoek
The overall hypothesis of this study is that exposures in early life (fetal period and early childhood) are associated with health outcomes in later life.
Onderzoeksopzet
Pregnancy
Birth
Infancy
Childhood (5 and 9 years)
Adolescence (13 and 16 years)
Onderzoeksproduct en/of interventie
None, observational cohort study
Publiek
P.O.Box 2040
Rotterdam 3000 CA
The Netherlands
+31 10 70 43405
generationr@erasmusmc.nl
Wetenschappelijk
P.O.Box 2040
Rotterdam 3000 CA
The Netherlands
+31 10 70 43405
generationr@erasmusmc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Pregnant women living in Rotterdam, the Netherlands, with a delivery date between April 2002 and January 2006.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
None
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL6484 |
NTR-old | NTR6671 |
Ander register | MEC-2012-165, NL40020.078.12; MEC 198.782/2001/31 : Erasmus MC |