It will be investigated whether passive leg raising and stroke volume variations can be used in predicting renal responses to fluid administration. Our hypothesis is that dynamic predictors of cardiac fluid responsiveness can predict an increase in…
Bron
Aandoening
acute kidney injury, oliguria, anuria, fluid responsiveness, renale response, passive leg raising, stroke volume variation
Ondersteuning
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
increase in diuresis of >10%
Doel van het onderzoek
It will be investigated whether passive leg raising and stroke volume variations can be used in predicting renal responses to fluid administration. Our hypothesis is that dynamic predictors of cardiac fluid responsiveness can predict an increase in diuresis, rather than static haemodynamic parameters and prerenal biochemical indices as fractional sodium excretion. This can lead to optimal fluid loading in intensive care patients with oliguria to prevent acute kidney injury and fluid overloading.
Onderzoeksopzet
t=0, t=60, t=120, t=180 (minutes)
Onderzoeksproduct en/of interventie
Thirty-five patients who are admitted to the Intensive Care Unit with diuresis <0.5 ml/kg/hr after proper initial resuscitation will be measured during a passive leg raising test and subsequently a fluid infusion of 1 L Ringers lactate in 1 hour, which is part of standard treatment. Stroke volume variation (SVV) by Flotrac/Vigileo (Edwards) and static haemodynamic parameters will be monitored during PLR and during fluid infusion. Diuresis an hour before the PLR and up to 2 hours after fluid infusion will be monitored.
Publiek
Arthur Melchers
Amsterdam
The Netherlands
a.j.melchers@amc.uva.nl
Wetenschappelijk
Arthur Melchers
Amsterdam
The Netherlands
a.j.melchers@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Age 21 to 80 years
- Mechanically ventilated patients
- Oliguria (diuresis <0.5 ml/kg/hr) after the initial resuscitation period at the ICU
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- medical ground
- ethical grounds
- Loss of blood >100 ml per hour
- relevant alterations in inotropic or vasopressor medication.
- Use of clinically relevant diuretics (furosemide, bumetanide, hydrochlorothiazide during the research protocol)
- a known medical history of significant heart failure requiring daily administration of high dose diuretics.
- pulmonary edema.
- pregnancy
- practical drawbacks
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL4889 |
NTR-old | NTR5126 |
Ander register | Medical Ethical Committee Noord-Holland : M014-035 |