Blue Light Imaging (BLI) and Linked Color Imaging (LCI) have additional value for the visualization of Barrett's neoplasia, when compared to White Light Endoscopy (WLE).
ID
Bron
Verkorte titel
Aandoening
Barrett's neoplasia
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Delineation scores:
a) Percentage of the ground truth delineation delineated;
b) AND/OR score for the ground truth delineation;
c) Difference in delineation scores for different levels of endoscopic experience;
VAS- and ordinal scores for assessment per lesion:
a) Characterization (Paris classification and surface relief);
b) Delineation;
c) Difference in scores for different levels of endoscopic experience;
Achtergrond van het onderzoek
A recent study performed by our group showed additional value for BLI for the visualization of BE neoplasia, when assessed by experts. Experts appreciated BLI better than WLE for visualization and delineation of BE neoplasia. Furthermore, their quantitative agreement increased significantly when BLI was offered next to WLE for lesions that were hard to delineate with WLE alone.
The aim of this study is to evaluate BLI and LCI as an additional tool next to WLE for the use of visualization and delineation of early Barrett neoplasia, when used by endoscopists with different levels of endoscopic expertise.
Doel van het onderzoek
Blue Light Imaging (BLI) and Linked Color Imaging (LCI) have additional value for the visualization of Barrett's neoplasia, when compared to White Light Endoscopy (WLE).
Onderzoeksopzet
This study is divided in 4 separate assessment phases, in which the endoscopic images will be scored and delineated by the assessors. Each phase is separated by a wash-out period of 2 weeks.
Phase 1: Only WLE images are shown (n=30)
Phase 2: WLE and BLI images are shown (n=15), WLE and LCI images are shown (n=15)
Phase 3: WLE and LCI images are shown (n=15), WLE and BLI images are shown (n=15)
Phase 4: WLE, BLI and LCI images are shown (n=30)
Onderzoeksproduct en/of interventie
n.a.
Publiek
Jeroen de Groof
+31 20 5664571
a.j.degroof@amc.uva.nl
Wetenschappelijk
Jeroen de Groof
+31 20 5664571
a.j.degroof@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Data from our previous study will be used (doi: 10.1016/j.gie.2018.10.046.). No new patient data will be collected.
A group of 90 international endoscopist assessors (30 fellows, 30 junior GE, 30 senior GE) will assess the endoscopic images collected in the previous study.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Data from our previous study will be used (doi: 10.1016/j.gie.2018.10.046.). No new patient data will be collected.
A group of 90 international endoscopist assessors (30 fellows, 30 junior GE, 30 senior GE) will assess the endoscopic images collected in the previous study.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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| Register | ID |
|---|---|
| NTR-new | NL7541 |
| Ander register | METC AMC : W15_068 |