ICG can be used to assess the gastric conduit perfusion during esophagectomy
ID
Bron
Verkorte titel
Aandoening
Esophageal cancer, Fluorescence, NIRF, ICG
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
To explore the feasibility and added value of intra-operative NIRF imaging to assess gastric conduit perfusion in minimally invasive esophagectomy.
Achtergrond van het onderzoek
Anastomotic leakage after esophagectomy is an early post-operative complication and a major cause of morbidity and mortality. Impaired arterial bloodflow of the gastric conduit is thought to be the most important cause of anastomotic leakage. Better assessment of gastric conduit perfusion and identification of the ideal level of anastomosis is needed. A promosing technique to assess the gastric conduit perfusion intra-operatively is near-infrared fluorescence (NIRF) imaging after injection with indocyanine green (ICG).
Doel van het onderzoek
ICG can be used to assess the gastric conduit perfusion during esophagectomy
Onderzoeksopzet
-
Onderzoeksproduct en/of interventie
Near-infrared fluorescence (NIRF) intra-operative imaging after administration of ICG
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
• All patients eligible for minimally invasive esophagectomy for esophageal cancer, with gastric conduit reconstruction and intra-thoracic gastro-esophageal anastomosis
• Aged 18 years or older
• Providing informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
• Known pregnancy or breastfeeding
• Known iodine, shellfish or ICG hypersensitivity
• Known hyper-thyroidism
• Known liver or renal insufficiency
• Unable to provide informed consent
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL5852 |
| NTR-old | NTR6032 |
| CCMO | NL58179.091.16 |
| OMON | NL-OMON45919 |