Immunogenicity and adjuvant effect of the whole cell Pertussis component of the Dutch combined Diphtheria, Tetanus, Pertussis, Poliomyelitis ~ Haemophilus influenzae type b vaccine in infants compared to the old whole cell P vaccine and a new acellular P vaccine component.

This study is undertaken to monitor the effects of the changes in the pertussis component of the DTP IPV-Hib vaccine as used in the Dutch National Immunisation Programme. There are 4 study groups consisting of 11 month old children who receive the DTp IPV-Hib vaccine with different pertussis components; a whole cell, 3 component acellular, 5 component acellular and a 5 component acellular with concurrent pneumococcal vaccination. The antibody respons is measured before vaccination at 11 months old and 4-8 weeks after vaccination by ELISAs.

To compare the immunogenicity of the whole cell versus the acellular pertussis component of the DTP IPV-Hib vaccine as measured by the antibody titers at 11 months before the 4th vaccination and at 12 months.

N/A

4 groups of 75 children aged 11 months:

1. DTwP IPV-Hib primary series and booster (11 months) (n=32);

2. DTwP IPV-Hib primary series and DTaP IPV-Hib booster (Infanrix) (n=79);

3. DTaP IPV-Hib (Infanrix) primary series and booster (n=95);

4. DTaP IPV-Hib (Pediacel) primary series and booster with (n=75) and without (n=75) pneumococcal vaccination (Prevenar).