IMRT treatment planning and irradiation in prone position can reduce the dose to the small bowel.
ID
Bron
Aandoening
DVH, radiotherapy, prone position, belly board, gynaecologic tumor, rectal cancer, small bowel, toxicity, organs at risk, IMRT
DVH, radiotherapie, buikligging, gynaecologische tumor, rectumcarcinoom, dunne darm, toxicity, risico organen.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Coverage of the PTV;<br>
2. Dmean of the small bowel (mean dose in the small bowel);<br>
3. V15 and V45 of the small bowel (volume of the small bowel which receives respectively 15 and 45Gy).
Achtergrond van het onderzoek
The aim of this study is to determine if in patients who are referred for pelvic irradiation, IMRT planning (in contrast to conformal 3D planning) gives the lowest dose to the small bowel without increasing the dose in other organs at risk (bladder, kidneys, rectum and sigmoid). In addition, we want to determine in which patients (postoperative endometrial and/or cervical and/or rectal cancer patients), according to dose volume histograms, irradiation in prone position is superior to supine position. For this, we need to make two, instead of one, consecutive CT-scans in prone and supine position respectively, and delineate on both scans the target organs as well as the organs at risk. Finally, we need to make four treatment plans for every patient, namely one IMRT plan in supine position, one IMRT plan in prone position, one 3D conformal plan in supine position and one 3D conformal plan in prone position and compare these plans with each other.
Doel van het onderzoek
IMRT treatment planning and irradiation in prone position can reduce the dose to the small bowel.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
One extra CT scan before start radiotherapy.
Publiek
G.H. Westerveld
Academic Medical Center
Amsterdam 1100 DD
The Netherlands
g.h.westerveld@amc.uva.nl
Wetenschappelijk
G.H. Westerveld
Academic Medical Center
Amsterdam 1100 DD
The Netherlands
g.h.westerveld@amc.uva.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients who are referred to our Radiotherapy department for pelvic irradiation for a gynaecologic or rectal malignancy;
2. Patients should be able to lie in prone position on a belly-board.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Unable to lie on a belly-board;
2. Allergic to iv-contrast;
3. Kidney failure (calculated GFR < 60ml/min);
4. Need for irradiation of the para-aortic lymph nodes.
Opzet
Deelname
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL2443 |
| NTR-old | NTR2552 |
| Ander register | MEC / CCMO : 10/188 / NL33187.018.10 ; |