The effect of tianeptine (antidepressant) on the respiratory depression caused by painkillers

Healhty volunteers (male/female)

- Age of 18 to 35 years (inclusive);

- Body Mass Index (BMI) between 18 and 35 kg/m2 (inclusive) and body weight
between 50 kg and 100 kg (inclusive);

- Subject is able to read and understand the written consent form, complete
study‐related procedures, and communicate with the study staff;

- Subject is willing to comply with study restrictions

-Clinically relevant abnormal history of physical and mental health, as determined
by medical history taking and physical examinations obtained during the
screening visit and/or prior to the administration of the initial dose of the study drug (as judged by the investigator);

- A semi recumbent systolic blood pressure of >160 mmHg and/or diastolic blood
pressure of > 95 mmHg at screening;

- History of alcoholism or substance abuse within three years prior to screening;

- Positive pregnancy test;

- Subjects using more than 20 units of alcohol per week;

- Use of medication during the study period;

- If sexually active, the subject is not using oral contraceptives, or surgically
sterilized;

- Subject has a history of severe allergies, or has had an anaphylactic reaction or
significant intolerability to prescription or non‐prescription drugs or food;

- Participation in an investigational drug trial in the 2 months prior to
administration of the initial dose of study drug or more than 5 times per year;

- Any other condition that in the opinion of the investigator would complicate or
compromise the study, or the well being of the subject.