We expect changes in each of the three tasks, with less words remembered (15 word test), a larger Simon effect (Simon task) and slower performance (TMT) in the repeated assessment compared to the first assessment. We also expect changes in each of…
Bron
Verkorte titel
Aandoening
The participants to this study are healthy adults.
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Cognitive measures: Number of words remembered (15 word test), variable representing the Simon effect for inhibition (Simon task), completion time (TMT).
Imaging measures as derived from MRI scans: Whole brain grey matter volume, cortical thickness in the superior frontal gyrus, FA of the prefrontal cortex
Achtergrond van het onderzoek
This study aims at gaining a broad picture of age-related changes in brain structure and cognitive functioning in a group of older adults by using a longitudinal within‐subjects design. The majority of previous studies examining the effects of age on brain and cognition have used cross-sectional designs, that is, comparing groups of young- and older adults in order to examine the effects of age. The proposed study provides an effort to overcome the problems associated to cross-sectional research by examining the dynamics of age-related changes from a longitudinal perspective. Furthermore, structural and functional changes over time will be associated to major life events, such as reduction in working time and retirement.
Doel van het onderzoek
We expect changes in each of the three tasks, with less words remembered (15 word test), a larger Simon effect (Simon task) and slower performance (TMT) in the repeated assessment compared to the first assessment. We also expect changes in each of the three main structural measures: Whole brain grey matter volume (smaller over time), cortical thickness in the superior frontal gyrus (thinner over time), and FA of the prefrontal cortex (lower over time).
Onderzoeksopzet
One time point, scheduled approximately 2 years after participating in the study 'Age and performance: the relation between brain structure and cognition'
Onderzoeksproduct en/of interventie
not applicable
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Having participated in the study ‘Age and performance: the relation between brain structure and cognition’.
- Right-handed
- Normal (or corrected to normal) vision
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
Not matching any of the inclusion criteria, as well as matching any criterion in the MRI exclusion list, including, but not limited to, claustrophobia, infarctions, epilepsy or family history of epilepsy, presence of metal inside the body, presence of electric/electronic devices inside the body (pacemakers, etc.), and presence of intracardial lines. We will exclude users of non-removable dentures, psychoactive medication, including antidepressants, anxiolytic, and anti-epileptic drugs, as well as cannabis, XTC or other recreational drugs.
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
Toelichting
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
Register | ID |
---|---|
NTR-new | NL7637 |
Ander register | METc Groningen : METc 2019.160 |