The use of by filtration-leukocyte reduced blood transfusions in patients undergoing cardiac surgery, will result in lower alloimmunization frequencies compared to using buffy-coat depleted blood transfusions. This has previously been shown in…
ID
Bron
Verkorte titel
Aandoening
Open heart surgery: CABG, heart valve surgery and the combination of both.
Ondersteuning
Red Cross Blood Bank Leidsenhage, Leiden
Red Cross Blood Bank Leidsenhage, Leiden;
NPBI bv, Emmer-Compascuum
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Anti-HLA antibody formation (tested by LCT)and anti-erythrocyte antibody formation (tested in 3 cell panel, with PEG).
Samples for analyses are collected before surgery, on day 7 post-surgery, 3-10 weeks post-surgery and 20-30 weeks post-surgery.
Achtergrond van het onderzoek
Primary outcome and most secundary outcomes are published.
Follow-up on long-term effects (decades) is still running.
Doel van het onderzoek
The use of by filtration-leukocyte reduced blood transfusions in patients undergoing cardiac surgery, will result in lower alloimmunization frequencies compared to using buffy-coat depleted blood transfusions. This has previously been shown in frequently transfused patients that received transfusions over a longer period of time, and is now investigated in patients receiving several units of blood around a single event, cardiac surgery.
Second hypothesis: If post-storage filtration is as effective as pre-storage filtration is also to being investigated in this study.
Onderzoeksopzet
N/A
Onderzoeksproduct en/of interventie
Use of by filtration leukocyte reduced blood transfusions vs use of buffy-coat depleted blood transfusions (=1990's standard in NL).
Publiek
Plesmanlaan 1a
L.M.G. Watering, van de
Plesmanlaan 1a
Leiden 2333 BZ
The Netherlands
+31 (0)71 5685053
Wetenschappelijk
Plesmanlaan 1a
L.M.G. Watering, van de
Plesmanlaan 1a
Leiden 2333 BZ
The Netherlands
+31 (0)71 5685053
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Patients planned for open heart surgery:
CABG, heart valve surgery or the combination of both.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Age < 18 year;
2. Transfusions within last 6 months;
3. Pre-existing medical indication for filtered blood products.
Opzet
Deelname
Opgevolgd door onderstaande (mogelijk meer actuele) registratie
Geen registraties gevonden.
Andere (mogelijk minder actuele) registraties in dit register
Geen registraties gevonden.
In overige registers
| Register | ID |
|---|---|
| NTR-new | NL223 |
| NTR-old | NTR259 |
| Ander register | : N/A |
| ISRCTN | ISRCTN45666086 |
Samenvatting resultaten
Vox Sang. 2003; 84; 65-67<br>
Transfusion 2003; 43; 765-771<br>