This study will test the hypothesis that Sevoflurane attenuates oxidative damage, complement, enothelial, thrombocyt and neutrophil activation and inflammation to human ischemia reperfusion injury of the myocardium.
ID
Bron
Verkorte titel
Aandoening
Sevoflurane, Cardiac Surgery, Inflammation, Preconditioning
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
1. Factors related to the acute inflammatory response (IL-6, ICAM e.d.);<br>
2. Factors likely involved in pathophysiology of I/R injury (cytokines);<br>
3. Markers of myocardial injury (Trop/CK-MB).
Achtergrond van het onderzoek
In this study we will include a homogenous group to obtain information about the underlying mechanisms of influencing the inflammatory component by Sevoflurane. Obtained data will provide information about possible protection against I/R injury and the possible contribution of Sevoflurane to attenuate the inflammatory response, leading to a decline in morbidity and mortality rates.
Doel van het onderzoek
This study will test the hypothesis that Sevoflurane attenuates oxidative damage, complement, enothelial, thrombocyt and neutrophil activation and inflammation to human ischemia reperfusion injury of the myocardium.
Onderzoeksopzet
Baseline, OR and ICU (till 24 hours after surgery).
Onderzoeksproduct en/of interventie
Sevoflurane will be added to the blood cardioplegia mixture in the treatment cohort. The control-cohort will receive oxygen. Addition only when Heart-lungmachine is activated.
Blook will be taken several times, starting from 1 day pre-OR to 5 days post-OR.
Publiek
Department of CardioThoracic Surgery,
room D6-53,
P.O. Box 9600
R.J.M. Klautz
Leiden 2300 RC
The Netherlands
+31 (0)71 5264022
r.j.m.klautz@lumc.nl
Wetenschappelijk
Department of CardioThoracic Surgery,
room D6-53,
P.O. Box 9600
R.J.M. Klautz
Leiden 2300 RC
The Netherlands
+31 (0)71 5264022
r.j.m.klautz@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Acceptation for mitral valve surgery via sternotomy;
2. LV ejection fraction > 35%.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Acceptation for minimal invasive valve surgery;
2. Use of systemic corticosteroids;
3. Inability to introduce coronary sinus catheter;
4. Inability to sign informed consent or less than 18 years old;
5. Emergency operations.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
| Register | ID |
|---|---|
| NTR-new | NL1972 |
| NTR-old | NTR2089 |
| Ander register | METC LUMC Leiden : P09.136 |
| ISRCTN | ISRCTN wordt niet meer aangevraagd. |