High thrombogenicity and platelet reactivity are risk factors for postoperative micro-emboli on transcranial doppler and postoperative strokes.
ID
Bron
Verkorte titel
Aandoening
stroke
carotic endarterectomy
blood coagulation
platelet reactivity
beroerte
carotis endarteriectomie
bloedstolling
plaatjesfunctie
Ondersteuning
Onderzoeksproduct en/of interventie
Uitkomstmaten
Primaire uitkomstmaten
Amount of MES signals (mean and SD) during TCD monitoring start from the first postoperative hour during a period of 3 hours in relation to thrombogenicity and platelet reactivity
Achtergrond van het onderzoek
100 patients undergoing carotid endarterectomy will be included in the study. Before the surgical intervention coagulation parameters and platelet function will be determined using different laboratory test. Durin operation one more blood samplewill be obtained,10 minutes after the injection of heparin. After the operation patients will be monitored using TCD, starting from the first postoperative hour during 3 hours. Subsequently we will investigate whether or not there is a correlation between the markers and the amount of postoperative MES. Also correlations between markers and the occurence of stroke will be investigated. There will be a follow-up period of 1 year.
Doel van het onderzoek
High thrombogenicity and platelet reactivity are risk factors for postoperative micro-emboli on transcranial doppler and postoperative strokes.
Onderzoeksopzet
T1= operation day -1: blood sample
T2= during operation: blood sample
T3= first 3 hours after the operation: TCD
T4= operation day +7: MRI cerebrum
T5= operation day + 365: clinical follow-up
Onderzoeksproduct en/of interventie
1) 2 bloodsamples at T1 and T2 for Callibrated Automated Thrombogram and for coagulation factors and platet function tests.
2) Transcranial Doppler sonography at T3. The amount of MES are measured during a period of 3 hours starting from the first postoperative hour.
3) MRI at T4
Algemeen / deelnemers
Department of Biochemistry K4.360
K. Winckers
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
+31 (0)43 3881685
kristien.winckers@bioch.unimaas.nl
Wetenschappers
Department of Biochemistry K4.360
K. Winckers
Universiteitssingel 50
Maastricht 6229 ER
The Netherlands
+31 (0)43 3881685
kristien.winckers@bioch.unimaas.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
1. Patients with an ischemic stroke or TIA (first episode or recurrent disease) AND:
an ipislateral stenosis of the carotid artery for which operation of the carotid artery is indicated.
2. Patients need to have an adequate transtemporal window for TCD monitoring og the ateria cerebri media
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Proven coagulopathies
2. Pregnancy
3. Active infections
4. Chronic inflammatory diseases
5. Anti-phospholipid syndrome
6. Active malignancy
7. Recent cardiovascular intervention (< 3 months)
8. Cardiac arrythmias
9. Postradiation stenosis of the carotid artery
Opzet
Deelname
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| Register | ID |
|---|---|
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| NTR-old | NTR1472 |
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