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Effects of acute exercise on acetylcarnitine concentration in endurance trained- and untrained subjects

The major research objective is to examine if acute exercise results in a more pronounced increase in acetylcarnitine concentration in sedentary subjects compared to endurance-trained subjects and if the exercise-induced increase in acetylcarnitine…

RAndomized comParison between the STENTYS self-aPpOSIng Sirolimus-eluting Coronary STent and a balloon-expandable stent In AcuTe MyocardIal InfarctiON

The objective of this study is to evaluate whether two different stent technologies (a self-expandable stent and a balloon-expandable stent) may be associated with different stent strut apposition and a variety of stent strut coverage with…

Prospective, pharmacokinetic study for determination of the relationship between lean body weight and anti-Xa activity 4 hours after subcutaneous administration of 5700 IU nadroparin in morbidly obese patients after bariatric surgery.

Primary objective: prospective evaluation of the relationship between lean body weight and anti-Xa activity of 5700 IU nadroparin 4 hours after subcutaneous administration in morbidly obese patients.Secundary objectives: - Correlation between other…

A multicenter, double blind, randomized, parallel group, placebo-controlled study to evaluate the hemodynamic responses to intravenous RLX030 infusion in subjects with acute heart failure.

Primary objective(s)• To assess the effects of RLX030 compared to placebo on hemodynamic variables (PCWP, CI) during the first 8 hours administered as i.v. infusion over 20 hours in subjects with Acute Hart FailureSecondary objective(s)• To assess…

MRI verified accuracy of intracompartmental pressure measurement in the deep posterior compartment of the lower leg: a pilot study

To analyse the accuracy of the positioning of the catheter that is used for pressure measurement deep flexor muscles of the lower leg using magnetic resonance imaging (MRI).

Evaluation of the Origo prototype for enhancing women*s labor & delivery experience. A pilot study.

The objective of this study is to gain insights into the value of the proposition *Origo* for women and their loved ones, medical staff and care institution.

BONE MINERAL DENSITY IN PROSTATE CANCER PATIENTS TREATED WITH ANDROGEN DEPRIVATION THERAPY

To assess whether a change in BMD as detected big DXA (gold standard) is comparable with the decline measured by the achilles method

Pituitary hormone secretion in patients with IGSF1 mutation

The objective of the current proposal is to further explore the pathophysiological changes that occur in patient with an IGSF1 mutation, using an established method for assessing hormone secretory characteristics.

LOw versus COnventional Tidal Volumes during One-lung Ventilation for Minimally Invasive Esophagectomy - A Randomized Controlled Trial

We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…

Using the Vestibular Labyrinthine Substitution system in daily life

To objectify the effect of the VLS-system during daily use regarding postural stability and quality of life.

Excitability of the motor cortex during motor imagery and observation in patients with Complex Regional Pain Syndrome (CRPS) and tonic dystonia

to find evidence for frontal inhibition during planning of explicit movements just as seen in patients with conversion disorders.

Reduction compression period of the arteria radialis after diagnostic cardiac catheterization.

To describe the differences in safety, patient comfort and admission period after diagnostic cardiac catheterization through radial access, between the current protocol and the protocol of fast desufflation by Carrington et al.

Vitamin D deficiency in patients with a fracture in the upper or lower extremity: a monocenter cross-sectional study

In the present study the prevalence of and risk factors for vitamin D deficiency will be determined in a patient population with a fracture in the upper or lower extremity.

The effectiveness of a serious game for children with ADHD: A randomized, controlled, multicenter trial.

The primary objective of this study is to examine the effectiveness of the serious game called HealSeeker for improving time management, planning and organisation and social behaviour skills of children with ADHD. The secondary objective of this…

A randomized phase II multicenter study with a safety run-in to assess the tolerability and efficacy of the addition of oral tosedostat to standard induction therapy in AML and RAEB >= 66 years and very poor risk AML >= 18 years.;A study in the frame of the masterprotocol of parallel randomized phase II studies in elderly AML

Primary objectivesPart A of the study (if applicable):1. To assess the safety and tolerability of tosedostat added to standard induction chemotherapy for AMLand select the feasible dose level for part B of the study2. To assess in a randomized…

Effect of mild therapeutic hypothermia in post cardiac arrest patients on inflammatory response

We want to describe in detail the MTH-induced changes in pro- and anti-inflammatory markers in patients after CA. We further aim to evaluate the relation between neurological outcome and levels of pro- and anti-inflammatory markers.

A phase I/II, open-label, dose-escalating study to evaluate the safety, tolerability and pharmacokinetics of twice daily oral midostaurin and to evaluate the preliminary clinical and pharmacodynamic response in pediatric patients with relapsed or refractory leukemia

This is a phase I/II pediatric dose-ranging study that will evaluate the safety, tolerability and pharmacokinetics of midostaurin in children <18 years of age and >= 3 months who have relapsed or refractory leukemias that may benefit…

the Application of an Electronic Nose in the Early detection of Aspergillosis II

1. To establish whether serial exhaled breath analysis using eNose can detect invasive pulmonary aspergillosis in patients with prolonged chemotherapy induced neutropenia (neutrophil counts <0.5 x 10^9 for more than 7 days).2. To establish…

Feasibility study of an ambulatory closed-loop system for the automated control of blood glucose with remote monitoring in type 1 diabetes (The Diabetes Assistant) - DiAs Trial

The objective is to sequentially test, validate, obtain regulatory approval for, and deploy at home, a closed-loop Control-to-Range (CTR) system comprising two algorithmic components: a Safety Supervision Module (SSM) and an automated Range…

Effect of cholecalciferol on the systolic blood pressure in hypertensive, vitamine D insufficient patients.

To evaluate the effect of cholecalciferol supplection on the systolic blood pressure in hypertensive patients with a 25-hydroxycholecalciferol insufficiency. Secondly, the effects on PRA, aldosteron, 25-hydroxycholecalciferol, alkaline phosphatase,…