123 results
To determine the effects of biphosphonates on radiation induced microvascular damage in the skin of breast cancer patients by comparing skin biopsies taken prior to and 4 months after treatment with a biphosphonate.
Primary Objective: To define a top set of genes that most reliably (r >=0.95) distinguish psoriasis from normal skin. We will define this set from differential methylation genes to indicate potential biomarkers.Secondary Objective(s):…
Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…
This study will investigate the effect of shear and pressure on tissue viability of human skin. Skin vitality is determined by tissue oxygenation and blood flow, measured with the 'Oxygen to See'. The focus will be on individual response…
Objective: We want to extend our understanding of the disease aetiology by performing a small pilot study that incorporates other immunologic sites involved in the disease (the skin and the microbiome) while additionally strengthening our disease…
To investigate biomarkers that play a role in the induction and resolution of AD.Secondary objective: to develop therapeutic interventions (pharmacologically) based on the revealed biomarkers.
The primary objective of this study is to evaluate whether the recovery of the skin barrier after acute perturbation by repetitive application of adhesive tape (*tape stripping*) is accelerated following irradiation with visible light. The secondary…
To investigate whether the upregulation of CK16 and Ki-67 (a marker for cell proliferation) in the FPSU is specific for HS, measured in inflammatory nodules and pseudo-comedones, in comparison to other dermatologic conditions that have comparable (…
1. To characterize long-term neurologic- and cognitive disorders, audiological and ophthalmological alterations in cCMV-infected children.2. To identify immunological, neurological host factors and virological factors that are predictive of…
This is a pilot study with the objective of studying the effect of vaselin on TSLP expression in nonlesional human AD skin.
The objective of this study is to analyse the microbiome of the skin of patients with ichthyosis vulgaris (FLG -/-). This microbiome will be compared to the microbiome of healthy volunteers (FLG +/+) and first grade family members of patients with…
In the present study we sought to determine the levels of IL-1 cytokines in the SC and to relate them to FLG genotype, pH and the levels of filaggrin degradation products. Furthermore, we aim to investigate whether FLG genotype status relates to the…
This single-center investigation will assess the prevalence of psoriasis in a population of patients with hepatitis C and compare the prevalence in those patients receiving pegylated interferon-* therapy to those not receiving pegylated interferon…
The major aim is to apply deep sequencing technology to obtain a detailed unbiased overview of the bacterial microbiome of human skin. This will be performed in healthy individuals, psoriasis patients and atopic dermatitis patients. Furthermore, we…
The objective of the study is mapping and assessing of the effects of filaggrin mutation on atopic eczema and other atopic diseases together with serological parameters.
The aim of this study is to detect the hitherto unknown factors which possibly can explain the difference in acetylation. Therefore we need to collect blood from PPD allergic patients and healthy volunteers, to determine not only the genotype, but…
In the present project we would like to find out whether we can observe Treg into Th17 conversion in lesional skin and in the peripheral blood of patients with AD and compare the results to our findings in psoriatic patients and healthy controls.…
Setup method for detection of STAT3 phosphorylation in human blood derived from patients with various chronic inflammatory diseases.Test the effect of new compounds on this phosphorylation process.
ACT reduces the incidence of PTS after DVT. In the Dutch CBO-guidelines current therapy is adviced for 2 years after diagnosis because most PTS develops within 2 years after DVT, with a peak incidence in the first year.Some clinicians claim that one…
With this project we would like to answer the following questions:To what extent do we observe Treg toTh17 conversion in inflammation of the human skin, as elicited in response to general standardized skin injury (i.e. tape-stripping and topical…