Walking fatigability and the relation to walking economy and walking quality and the impact on social role participation and daily life activity in persons with Multiple Sclerosis.

Walking capacity is reported as one of the most important bodily functions for
maintaining a high quality of life in persons with Multiple Sclerosis (pwMS).
It has been shown that limitations in walking capacity in pwMS are related to
fatigue, which subsequently leads to a decreased daily physical activity. This
may impact physical fitness and ultimately lead to a decreased social role
participation. However, it is not well known whether this limitation in walking
capacity, measured during walking (walking fatigability) is related to less
energy efficient walking and thus a poor walking economy. It is proposed that
assessing the relation between walking fatigability, walking economy and
walking characteristics (e.g. spatiotemporal parameters, kinematic and kinetic
profiles, muscle coordination patterns) can lead to a better understanding of
the determinants of fatigue and walking fatigability in pwMS. In addition,
exploring its impact on daily activities and social participation will aid
rehabilitation of pwMS .

The main objective is to investigate the association between walking
fatigability during the 6 minute walking test (6MWT) and walking economy in
pwMS who are able to walk independently. Secondary objectives are to
investigate the role of I. walking characteristics II. daily life activity and
III. social role participation and quality of life on walking fatigability and
economy in pwMS

Observational cross-sectional study

The participants can feel fatigued after performing the 6 minute walking test