No registrations found.
ID
Source
Brief title
Health condition
Multiple Sclerosis
Sponsors and support
Intervention
Outcome measures
Primary outcome
Walking fatigability
Secondary outcome
Walking economy
Background summary
Walking capacity is reported as one of the most important bodily functions for maintaining a high quality of life in persons with Multiple Sclerosis (pwMS). It has been shown that limitations in walking capacity in pwMS are related to fatigue, which subsequently leads to a decreased daily physical activity. This may impact physical fitness and ultimately lead to a decreased social role participation. However, it is not well known whether this limitation in walking capacity, measured during walking is related to less energy efficient walking and thus a poor walking economy. It is proposed that assessing the relation between a decline in walking capacity (walking fatigability), walking economy and walking characteristics (e.g. spatiotemporal parameters, kinematic and kinetic profiles, muscle coordination patterns) can lead to a better understanding of the determinants of walking fatigue in pwMS. In addition, exploring its impact on daily activities and social participation will aid rehabilitation of pwMS .
Study objective
It is hypothesized that persons with MS have a higher energetic cost of walking due to more variability in gait parameters.
Study design
1
Inclusion criteria
- Diagnosed MS by neurologist
- Expanded Disability Status Scale 1- 5.5
- Able to walk without walking aid and orthoses
- Age between 18-65 years
Exclusion criteria
- Recent (3months) relapse
- Recent (12 months) arthroplasty or fracture
- Comorbidities affecting functioning (such as diabetes mellitus, malignancies)
- Contra-indication for physical activity or exertion tests
- Botulinum treatment in lower extremity <6 months before measurement
Design
Recruitment
IPD sharing statement
Followed up by the following (possibly more current) registration
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| NTR-new | NL7921 |
| CCMO | NL67805.068.18 |
| OMON | NL-OMON49047 |