69 results
Primary objective: To improve outcome prediction in sFGR by developing a prediction model at the time of sFGR diagnosis and by evaluating specific ultrasound parameters throughout the pregnancy. Secondary objectives: - To increase our knowledge of…
This study has been transitioned to CTIS with ID 2024-518669-83-00 check the CTIS register for the current data. Primary objective:To assess, in an international pediatric study, the efficacy, in terms of event-free survival, of a combination of ATO…
The aim of this study is to identify whether the availability of a PSD for military veterans with PTSD coincides with clinically significant changes in wellbeing, behaviour and functioning in veterans and their families compared to veterans with…
With the extended LAST STRONG Study, we aim to (1) collect 3-year and 5-year natural history data, (2) implement the natural history data collection into clinical care and international guidelines (reach trial readiness), and (3) do in-depth…
Primary Efficacy Objective (Blinded Treatment Period)• To demonstrate the efficacy of rilzabrutinib versus placebo in participants with refractory/relapsed ITP, based on the durability of platelet response during the last12 weeks of the 24-week…
This study has been transitioned to CTIS with ID 2023-505000-27-01 check the CTIS register for the current data. To investigate the safety and efficacy of quizartinib in children and adolescents with newly diagnosed FLT3-ITD positive AML with normal…
The aim of this study is to improve the conservative management of OCLs of the talus in the skeletally immature due to the comparison of two different conservative strategies. An optimal conservative treatment can result in a better quality of life…
To measure cardiac output at various levels of Positive End Expiratory Pressure (PEEP).
The primary objective is to investigate the efficacy of a magic-based intervention in alleviating short-term self-reported distress in children (7-18 years of age) undergoing catheter-based ablation for cardiac arrhythmias on the day of the…
(Also see METC- protocol)Primary Objective:To investigate the effectiveness of the SPACE treatment to improve family accommodation and OCD symptoms.Secondary Objective: To explore mechanisms of change (in OCD symptoms) for the effectiveness of the…
The aim of this study is to investigate the effectiveness of MST-ID for adolescents with severe behavioural problems from families with an intellectual disability (ID), compared to standard MST. It is hypothesised that MST-ID (n = 150 families) is…
To study in two national cohorts of HSCT survivors, treated in different time periods, the prevalence and risk factors of metabolic syndrome, endothelial dysfunction (as a sign of vascular damage) and the clinical phenotypes of accelerated aging so…
Our primary objective is to determine the prevalence of exercise induced laryngeal obstruction (EILO) in children with asthma. As secondary objectives, we aim to investigate 1) if there is a different prevalence of EILO in children with and without…
The aim of this study is to compare the outcome of a clinical challenge test and home introduction of cow*s milk for children with a suspected non-IgE-mediated cow*s milk allergy. We want to evaluate the ability of both tests to determine the…
Primary Objective:1. To validate the HLA-DQ typing in blood taken by a fingerprick; to make it feasible in the regular Preventive YHCCs organization.2. To establish the feasibility of HLA-DQ2/8 typing in the active case-finding at the Preventive…
Our primary objective is to assess the relation between itch and sustained attention in 7-11 year old children with atopic dermatitis (AD). Secondary objectives are to assess the relation between itch and task-oriented behavior, to assess whether…
This study has been transitioned to CTIS with ID 2024-511472-32-00 check the CTIS register for the current data. Primary for Platform-Level Exploratory Analysis1. To evaluate whether treatment with IL-23 inhibitors is superior to adult placebo in…
Primary Objective: to develop and evaluate a machine learning (ML) prediction model of brain injury in neonates at high-risk for CP to predict motor, behavioral, and cognitive outcome more accurately.This aim will be achieved by: developing and…
The objectives of this study are to (1) test the efficacy of sVRE versus CAU in 180 children undergoing surgery on the postoperative pain of the child (primary outcome), postoperative analgesics use, anxiety level of the child during induction of…
The primary objective of the cohort study is to test the effectiveness of a complex intervention of paediatric sleep problems on a 24-hour sleep duration (day- and nighttime) of children aged 6-36 months of age with sleep onset and/ or sleep…