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EMDR with traumatized adolescents with a major depressive disorder

The aim of this study is to investigate the effectiveness of EMDR with traumatized adolescents (12-18 years) with major depressive disorder.

Identification of novel childhood osteosarcoma predisposing genes.

To identify novel childhood osteosarcoma predisposing genes.

Macro- and microscopic mucosal characteristics of the biliopancreatic limb and excluded stomach after Roux-en-y gastric bypass

Determination of microbiological, macro and microscopic / histological characteristics after RYGB, mainly targeted at identifying inflammatory characteristics, bacterial (over) growth and / or atrophy / metaplasia in the excluded stomach and the…

Exploration of the modulation of skin microbiota and odor components by introduction of stress in healthy male subjects.

To determine whether the adapted Sternberg short-term working memory task (STMST) is an effective method to induce emotional stress-induced malodour.

A comparative, open-label, randomized, 2-stage sequential design, 2 periods, crossover study to demonstrate the bioequivalence of 2 FT218 batches (single dose of 4.5 gram) in healthy volunteers

The purpose of the study is to investigate how quickly and to what extent 2 different production batches of FT218 (batch A and batch B) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…

Coagulation improvement after platelet transfusion in critically ill patients

We propose an observational clinical trial in critically ill patients to investigate the effect and duration of platelet transfusion on coagulation, including platelet function and markers of endothelial activation in critically ill patients.

Evaluating blood biomarkers from healthy controls and patients with
age*related disease: Alzheimer*s disease

The primary objective is to evaluate plasma levels of A*1*42/A*1*40 ratio, A*1*40, A*1*42, neurofilament light (NFL), t*tau and anti*tau antibodies as disease*specific markers for AD. The secondary objective is to measure biological age parameters (…

A placebo-controlled, double-blind, randomized trial to evaluate the effect of 300 mg of inclisiran sodium given as subcutaneous injections in subjects with Atherosclerotic cardiovascular disease (ASCVD) or ASCVD- risk equivalents and elevated low density lipoprotein cholesterol (LDL-C)

The primary objective of this study is to evaluate the effect of inclisiran treatment on:•LDL-C levels at Day 510•Time adjusted percent change in LDL-C levels from baseline between Day 90 and Day 540 levels. The secondary objectives of this study…

A phase 1, open-label, 2-period, fixed sequence, study to investigate the absorption, metabolism and excretion of 14C-PF-06650833 and to assess the absolute bioavailability and fraction absorbed of PF-06650833 in healthy male subjects using a 14C-microdose approach.

The purpose of this study is to investigate how quickly and to what extent PF-06650833 is absorbed, distributed, metabolized (broken down) and eliminated from the body (this is called pharmacokinetics). PF-06650833 is not registered as a drug, but…

A Phase I, open-label, randomized, two-way crossover study to investigate the effects of morning versus evening repeated dosing on the pharmacokinetics of the combination of GLPG3067, GLPG2222 and GLPG2737 in healthy female subjects.

- To evaluate the pharmacokinetic (PK) profile of the combination of GLPG3067, GLPG2222, and GLPG2737 following repeated morning versus evening doses given to healthy female subjects - To evaluate the safety and tolerability of the combination of…

Autologous Dendritic Cells Loaded with Allogenic Tumor Lysate for Surgically Resected Pancreatic Cancer Patients (REACtiVe Trial)

To investigate feasibility, safety and toxicity as well as immune-response of an allogeneic tumor cell lysate (PheraLys) loaded onto autologous dendritic cells (MesoPher) in resected pancreatic cancer patients who received adjuvant standard of care…

Open label, randomized, cross-over study to explore the pharmacokinetics of BAY 1834845 after oral and intravenous dosing, including food effect and absolute bioavailability (Part A), and to investigate the effect of BAY 1834845 on the pharmacokinetics of orally administered methotrexate (Part B) in healthy male subjects

The purpose of the study is to investigate how quickly and to what extent BAY 1834845 is absorbed and eliminated from the body (this is called pharmacokinetics). In both study parts it will also be investigated to what extent BAY 1834845 is…

First dorsal interosseous muscle activation

1) To determine the effect of the level of voluntary force on the magnitude of superimposed twitches evoked using peripheral nerve stimulation (PNS), motor point stimulation (MPS), and transcranial magnetic stimulation (TMS) in first dorsal…

Randomized, double-blind, placebo-controlled oxytocin trial in children with Prader-Willi syndrome.
Effects on social behaviour.

To evaluate the effects of intranasal oxytocin versus placebo on social behaviour and also on eating behaviour in children with PWS.

A prospective trial on the clinical efficacy of the Ankle Spacer for the surgical treatment of large, multiple, cystic and secondary or tertiary osteochondral defects of the talus.

* Primary Objective: determine the functional outcome and clinical efficacy after open surgical implantation of the Ankle Spacer for patients with large, cystic, previously surgically failed and/or multiple OCDs of the talus by means of functional…

Investigating cardiovascular adverse events related to cancer treatment: a study of extreme toxicity using induced pluripotent stem cells

To identify the pathophysiology and predictors of study (extreme) cancer treatment -induced cardiovascular toxicity in cancer patients, by in vitro investigation of cardiovascular toxicity in patient-derived cardiomyocytes (iPSC-CMs) and endothelial…

EMDR for Misophonia, a pilot study

To evaluate the effect of Eye Movement Desensitisation and Reprocessing (EMDR) as an alternative or additional therapy for misophonia.

Glioma stem cell organoids: preclinical model of glioblastoma heterogeneity to explore resistance mechanisms to conventional treatment schedules.

to establish primary patient derived organoid cultures from GM to study mechanisms that contribute to aggressive tumor growth and treatment resistance in primary and recurrent GM.

A randomized, double-blind, placebo and positive controlled, parallel group study to investigate the QTc exposure response, pharmacokinetics, safetyand tolerability after multiple therapeutic and supratherapeutic dosing of etrasimod (APD334) in healthy adult subjects

The purpose of the study is to investigate the effect of etrasimod on the values of specific ECG parameters. Importantly, the study will assess whether there is a prolongation of the QT interval following etrasimod treatment. When the QT interval is…

A placebo-controlled, double-blind, randomized trial to evaluate the effect of 300 mg of inclisiran sodium given as subcutaneous injections in subjects with Atherosclerotic cardiovascular disease (ASCVD) or ASCVD- risk equivalents and elevated low density lipoprotein cholesterol (LDL-C)

The primary objective of this study is to evaluate the effect of inclisiran treatment on:*LDL-C levels at Day 510*Time adjusted percent change in LDL-C levels from baseline between Day 90 and Day 540 levelsThe secondary objectives of this study are…