113 results
Primary objective: To assess the impact of acute laser treatment on muscle tissue mitochondrial respiration in vivo in healthy, young adults. Secondary objective: To assess the impact of acute laser treatment on muscle cellular energy, anabolic,…
The aim of the current study is to determine the transport functionality, integrity, and viability in intestinal tissue obtained from patients who are expected to have a disturbed intestianl functionality due to severe obesity.
To support the validity of an in vitro colonic fermentation system, by demonstrating that changes in gut microbiota composition and functionality/metabolism, induced by prebiotics in the in vitro Microcolon model, are mimicking the changes that are…
Primary Objectives:Associated pharmaceutical trial:To compare the efficacy of disitamab vedotin in combination with pembrolizumab to chemotherapy as first-line treatment in participants with advanced UC that expresses HER2Clinical…
-To investigate the development of ETs through the role of platelets and activated endothelium by performing co-culture experiments with neutrophils, macrophages, platelets and renal-derived endothelial cells. -To determine whether deceased donor…
Our primary objective is to elucidate the neural and cognitive effects of short-term TUS to two thalamic subdivisions in humans. To this end, we target two thalamic subregions that are spatially adjacent yet feature divergent connectivity profiles…
The primary objective is to determine the incidence and severity of sicca complaints after ICI administration. The secondary objectives are: 1) to measure changes in objective measures of oral and ocular dryness after ICI administration; 2) to…
To investigate the frequency of V*9Vδ2-T cells in patients with metastatic castration-resistant prostate cancer
Primary objective: To determine the characteristics of language, speech and motor functions in MCI due to AD, mild AD and moderate AD Secondary objective: To explore the association between language, speech and motor functions in MCI due to AD and…
The study objective is to evaluate the efficiency of PerfusiX-Imaging compared to the current state of the art for perfusionmeasurements; indocyanine green fluorescence imaging. Also, feasibility and safety of PerfusiX-Imaging for perfusion…
Primary:Part A:. Evaluate the toxicodynamic variability in an evenly distributed cohort of male and female healthy volunteers Part B:. Evaluate the toxicodynamic variability among age, sex and ethnic backgrounds Exploratory:. Correlation of flow…
PrimaryInvestigate the seroprevalence of pre-existing antibodies to AAV in patients with PKP2-associated ARVCSecondaryTo characterize the burden of illness in patients with pathogenic or likely pathogenic PKP2 mutationsTo characterize arrhythmic…
The purpose of the investigation is to confirm the safety and efficacy of the InDx implant in treatment of CMC osteoarthritis.
Primary Objectives• To evaluate in vivo complement activation after first-time treatment with paclitaxel, liposomal doxorubicin (Caelyx) or other complement-reactogenic compounds• To evaluate ex vivo complement activation after incubation of predose…
The aim of this study is to evaluate the PAP treatment response in OSA patients during the first three weeks by monitoring the relevant objective and subjective sleep parameters.
To investigate the impact of different doses of handgrip exercises (moderate vs high intensity) and stimuli (exercise vs ischemia) on the ability to protect endothelial damage from ischemia-reperfusion injury in healthy humans. A secondary goal is…
The iBerry Study has two main study objectives:1. Descibing long-term prognosis of subclinical symptoms in terms of course (transition to several psychiatric disorders, chronicity, recurrence, comorbidiy) and public health consequences (disability…
By using advanced respiratory monitoring, we will aim to gain more understanding about the physiological effects and potential benefits of FCV in comparison to VCV in patients with an exacerbation of their asthma or COPD. We hypothesize that FCV in…
With this study we want to test the user experience of the prototype app and to develop a method to identify subtypes of post-covid patients and link this to demografic, medical and sociopychological characteristics as predictors.
Our main goal is to clarify the behavioural and neurophysiological effects of short-term TUS on deep brain circuits in humans. We will compare the effects of Amygdala-TUS, dACC-TUS and sham-TUS to one-another using a behavioural task and fMRI. Our…