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Efficiency, safety and feasibility of PerfusiX-Imaging for Gastro-Intestinal tissue perfusion assessment in humans.

The study objective is to evaluate the efficiency of PerfusiX-Imaging compared to the current state of the art for perfusion measurements; indocyanine green fluorescence imaging. Also, feasibility and safety of PerfusiX-Imaging for perfusion…

Trial readiness and fitness for congenital myopathies: A 2-year prospective natural history study including a cross-sectional study on muscle fatigability

Part 1: Assess the natural disease course of three congenital myopathies during 24 months. This will enable us to obtain a detailed assessment of the phenotype and genotype, evaluate and optimize the current care, determine the rate of disease…

The cost-effectiveness of contingency management compared to standard cognitive behavioral treatment for treating cannabis use disorder in youth: A randomized controlled trial

We aim to investigate in an RCT the (cost-)effectiveness of CM, compared with usual care CBT in the treatment of CUD in youths aged 16 to 22 years. Both outpatient treatments are provided for 12 weeks.PRIMARY STUDY QUESTION:1. What is the efficacy…

Immunological response after early extra and regular MMR immunization; 10 years follow-up

Primary Objective: - To assess the effect of MMR-0 vaccination on the humoral immunity against measles 2 years (+/- 2 months) after MMR-2 vaccination.Secondary Objective(s): - Determine the effect of MMR-0 vaccination on the humoral immunity against…

Validation of the Virtual Reality PainCart using diazepam: a randomized single center, double-blind, placebo-controlled, cross-over study investigating the affective component of pain

• To assess the change in electrical pain perception induced by virtual reality.• To assess the effect of diazepam on electrical pain perception. • To assess the relationship between the electrical pain perception and personality characteristics.

An Evaluation of the AeriSeal System for CONVERTing Collateral Ventilation Status in Patients with Severe Emphysema: The CONVERT II Trial

This study is to investigate the safety and effectiveness of the AeriSeal system in limiting collateral ventilation within a target lung lobe. And to achieve lung volume reduction using Zephyur Vavles and assess lung function, hyperinflations and…

PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients

The primary objective is to show that brain MRI surveillance alone is non-inferior in terms of overall survival (OS) to brain MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).

PROFID EHRA
PRevention Of sudden cardiac death aFter myocardial Infarction by Defibrillator im-
plantation

To demonstrate that in post-MI patients with symptomatic heart failure who receive optimal medical therapy (OMT) for this condition, and with reduced LVEF <=35%, OMT without implantable cardioverter defibrillator (ICD) implantation (index…