289 results
To determine the appropriateness of scale content of the preliminary CLEFT-Q scales by age and culture and to identify unclear or ambiguous items, instructions and response options
Objective: Development of an instrument to objectively assess arm-hand skilled performance in daily life in typically developing children, children with CP and adults who suffered a stroke.
To determine the differences in brain activation during (un)healthy food choice between normal weight and overweight groups of children (10-13 y) and their parents and relate those to subject characteristics.
Primary objective1) To study the frequency of mutations in this gene in patients with central hypothyroidism and their first- and second-degree relativesSecondary objective: 2) To determine the clinical, biochemical and radiological consequences of…
The aim of the study is to strengthen the basis for a new application of pupillometry (i.e., the measurement of pupil dilation) within the field of Audiology. An innovative method to quantify listening effort (pupillometry) will be further developed…
Objective of this study is to determine if Optical Coherence Tomography (OCT) measurements are a reliable measure of the severity of neurological impairment in patients with X-ALD and ZSD and therefore if OCT is an acceptable "surrogate"…
In this study we would like to find new biomarkers in BOS after haematopoietic stem cell transplantation (HSCT), that may lead to earlier identification of BOS than a lung function decline.
The aim of this proposal is threefold: (i) test a neuroscientific model of prosocial development by relating neuroscience discoveries to changes in several dimensions of prosocial development in a comprehensive study including children, adolescents…
The primary objective is to study if quantitative (3- and 7-Tesla) MRI protocols (MRI perfusion, diffusion tensor imaging (DTI), and chemical shift imaging (CSI)) are able to detect phenotype conversion earlier than conventional MRI. Results will be…
Evaluate the effect of menarche and menstrual cycle on the QTc interval among girls with genetically confirmed mutations causing LQTS type 1 (LQT1) and type 2 (LQT2).
To obtain a comprehensive overview of long-term (*5 years after burn injury) consequences after burn injuries, both in all patients admitted to burn centre admissions and in a subgroup of patients who suffered from more extensive burns.
To study feasibility, reliability and validity of a specific set of outcome measures in children with mitochondrial myopathy.
The primary objective is to assess neuropsychological function in X-ALD patients without active cerebral demyelinating disease. Data of minors will be compared to matched healthy controls. Data of adults will be compared to reference values. The…
To test if acute NK boosts muscle mitochondrial function in vivo in patients with VLCADD in order to establish a rational basis for therapeutic use in this disorder. A secondary objective is to gather data to test the working hypothesis that the…
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
First objective: gain insight in the coordination of trunk, head and arm during functional tasks in healthy children and compare this with the coordination in children with DMD, SMA and CP. Second objective: investigate if newly developed supportive…
In Phase 1 of the project, a systematic approach will be used to identify which factors add to the prediction of children*s clinical risk status. First, we will determine how well multiple assessments of behavioral problems (opposition, aggression,…
Since this cohort is at risk for many developmental problems, further follow-up on this cohort is warranted. We especially want to examine growth, pubertal development, and the neurocognitive- and behavioural development. Since we have many…
The primary objective of the REBEL study is to collect data needed to design control policies to diminish the spread of ESBL-producing Gram negative bacteria in the Dutch population.
The primary objective of this study is to identify parameters that predict bleeding risk in children with chronic ITP. Secondary objectives are: 1) To investigate whether children with long lasting chronic ITP differ from children with newly…