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Lifestyle InterVEntion Study in General Practice: LIVES - GP

Primary Objective:Our primary goal is to investigate the feasibility of a large pragmatic study of the effectiveness of a tailored MLI for patients with depression in general practice and to evaluate potential barriers and facilitators in a process…

A randomized, double-blind, dose-ranging, placebo-controlled, Phase 2a evaluation of the safety, tolerability, and pharmacokinetics of PLN-74809 in participants with primary sclerosing cholangitis (PSC) and suspected liver fibrosis (INTEGRIS-PSC)

To assess the safety and tolerability of PLN 74809 in participants with PSC and suspected liver fibrosis

Oligometastatic directed radiotherapy for patients with castration resistant prostate cancer.

The aim of the study is to investigate the effect of MDRT to the visible lesions in patients with omCRPC (up to 3 metastases and/or local recurrence) while continuing the ongoing systemic treatment. Progression is based on prostate specific membrane…

IDEAL phase IIa study of a newly designed Optical Coherence Tomography probe during transurethral resection for optimizing bladder cancer diagnosis and treatment

The primary objective:- To investigate the feasibility of capturing in-vivo cross section images of the bladder wall in bladder cancer patients with the OCT catheter.Secondary objectives:- To evaluate the duration of the OCT measurements. - To…

Adaptive anastomosis for anterior resection in sigmoid and proximal rectal cancer or premalignant lesions: a multicentre non-randomised clinical effectiveness trial (ADAPT)

The aim of this trial is to investigate the safety and efficacy of an adaptive anastomosis using the C-REX RectoAid Cath following elective anterior resection for sigmoid or proximal rectal cancer, or premalignant lesions not amenable tot endoscopic…

Adaptive Fractionation in Online-Adaptive Stereotactic Radiotherapy for Abdominopelvic Lymph Node Oligometastases

Primary: Can the number of online adaptive fractions be reduced by 30%?Secondary: What is the overall survival, local control, and toxicity? What is the movement of the bowel during treatment? Is there added value in re-aligning the patient when…

Platelet inhibition versus direct oral anticoagulation in patients undergoing percutaneous closure of patent foramen ovale or atrial septal defect

This study has been transitioned to CTIS with ID 2024-517115-70-00 check the CTIS register for the current data. Primary Objective: The goal of the study is to evaluate hemostasis, such as coagulation activation/thrombin generation and platelet…