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PIWIL1 ISH ASSAY CLINICAL PERFORMANCE STUDY IN FFPE SPECIMENS FROM SUBJECTS WITH ADVANCED TUMORS FOR ENROLMENT WITHIN THE CLINICAL TRIAL IMC-R117C-1004

To evaluate the clinical utility of the PIWIL1 ISH assay for predicting response of patients with Advanced PIWIL1-Positive Cancers within the lmmunocore clinical study. To determine the role of PIWIL1 expression as a potential predictor of efficacy…

Using Diffuse Reflectance Spectroscopy Probes to conduct Optical Measurements during Surgery for Colorectal Cancer

To assess the practical usability of our DRS probes for the detection of positive resection margins in colorectal cancer surgery - specifically whether they can be used in the confined surgical workfield in the lower pelvis - as well as the…

Home-based management of hypoxemic patients with acute respiratory tract infections. A complex intervention study with a randomized controlled trial embedded in a regional collaborative healthcare network.

The main objective of this study is to assess the feasibility, safety and (cost-)effectiveness of the HOME-ART intervention in comparison to regular hospital admission in patients with CA-ARTI.

Dose-intensified Image-Guided Fractionated Radiosurgery for Spinal Metastases (DOSIS)

To determine whether a sustained pain relief can be achieved with dose intensified hypofractionated image guided radiosurgery in patients with vertebral metastasis and a longer life expectancy

AN EVALUATIVE QUESTIONNAIRE STUDY OF FSIAD SYMPTOMATOLOGY, DISTRESS AND PREFERED MEDICATION USE IN WOMEN WITH FSIAD AND WOMEN WITH SELF-REPORTED SEXUAL INTEREST/AROUSAL PROBLEMS

1. To determine which FSIAD symptoms cause the most distress2. To determine which mode of medication administration is preferred and fits their problems best.

Pharmacokinetics of micafungin (Mycamin ®) as antifungal prophylaxis given twice weekly intravenously compared to micafungin given daily to patients at risk for developing an invasive fungal disease.

The primary objective of this trial is as follows:• To determine the pharmacokinetics of micafungin 300 mg given twice weekly on Mondays and Thursdays in patients at risk for developing an invasive fungal disease (patients who are being treated for…

The Effect of Ketone Monoester on Cognition in Neurotypical People of Different Ages

The general objective of this study is to investigate whether ketone monoester supplemention improves cognition. Cognition will beassessed by adaptive n-back test and task-switching test. The study will also investigate the effect of ketone…

A multi-center, double-blind, randomized, placebo-controlled, cross-over study to evaluate the efficacy, safety and tolerability of SAF312 in subjects with neurogenic detrusor overactivity due to spinal cord lesions who are inadequately managed by antimuscarinic therapy (CSAF312A2202)

Primary: effects of SAF312 on the Maximum Cystometric Capacity (changes from baseline) versus placebo following one-week treatment.Secondary: Evaluation of the safety, tolerability and PK, PK/PD, additional parameters examined during cystometry,…

Platelet inhibition versus direct oral anticoagulation in patients undergoing percutaneous closure of patent foramen ovale or atrial septal defect

This study has been transitioned to CTIS with ID 2024-517115-70-00 check the CTIS register for the current data. Primary Objective: The goal of the study is to evaluate hemostasis, such as coagulation activation/thrombin generation and platelet…