972 results
To assess the efficacy, measured as progression free survival, and safety of Selumetinib in combination with docetaxel, compared to docetaxel alone, in patients receiving second line treatment for KRAS mutation-positive, locally advanced or…
The main objective of our study is to explore whether LTH and FMD are correlated. Main secondary objectives are to investigate whether the LTH response is largely NO-mediated and whether drinking beetroot juice acutely improves both FMD and LTH.
Here we will perform a proof of concept study on the ability of the antidepressant tianeptine to prevent respiratory depression from the opioid alfentanil in humans.
The purpose of this study is to evaluate the efficacy and safety of MDV3100, a novel potent androgen-receptor antagonist without known agonist activity, in asymptomatic or mildly symptomatic patients with progressive metastatic prostate cancer who…
The investigators hypothesize that repetitive transcranial magnetic stimulation (rTMS) on the right side of the head will make craving towards alcohol less severe in recently detoxified alcohol addicted patients.In this study the investigators focus…
To evaluate the effects of intranasal oxytocin compared to placebo administration on appetite, satiety and food intake.Also effects on social behavior, BMI, body composition, IGF-I levels and genetic differences (deletion / mUPD). To assess oxytocin…
To research if total joint arthroplasty leads to better results than trapeziectomy on the long term, with subjective and objective outcome measures.
To investigate the effect of tourniquet application on the coagulation system in patients undergoing a knee arthroscopy. A finding of more prominent activation of the coagulation system with tourniquet use than with non-use will create an important…
To determine the efficacy and safety of laser therapy in diabetes patients with risk factors for developing diabetic foot complications.
In this study, we have the following research objectives:1. To examine if NF, by applying the above mentioned AA-protocol, is an efficacious treatment for major depressive disorder. We will conduct a RCT in which active NF will be compared to sham-…
We aim to examine, in the impaired older population, whether a treatment using methylphenidate, a DA re-uptake inhibitor that enhances DA, improves attention and memory.
The purpose of this study is to evaluate the safety of darbepoetin alfa, inclusive of the effects on survival and cancer progression, and the necessity of blood transfusions.
Primary Efficacy Objectives• To compare the overall survival (OS) in subjects with malignant pleural mesothelioma receiving VS-6063 or placebo.• To compare the progression free survival (PFS) in subjects with malignant pleural mesothelioma receiving…
Fundamental research with the objective to gain more insight in empathic processes within people suffering from psychopathy. Goal is to evaluate if affective empathic can be temporarily altered (in terms of minutes).
The ORANGE-II trial is a randomised controlled trial that will provide evidence on the merits of laparoscopic surgery in patients undergoing a left lateral hepatic sectionectomy and participating in an enhanced recovery programme.
The efficacy and safety of Lactobacillus plantarum 299v in patients with IBS will be investigated in a double-blind, randomised, placebo-controlled study. The Sponsor has earlier got an approved health claim in Sweden for gut health and intake of…
PrimaryImproved woundhealing in 30 days in patients with an open revascularisation of the lower extremities after treatment with 4 dosages of 2 grams ascorbic acid on 4 consecutive days. (First dosage 1 hour preoperative)SecondaryWith preoperative…
Primary Objective: • To determine the incidence rate of self-reported ILI.Secondary Objectives: • To determine the efficacy of 13vPnC in preventing a first episode of self-reported LRTI.• To explore the effect of 13vPnC on the incidence of self-…
Probleemstelling: Er is geen duidelijkheid of rTMS, toegepast binnen het reguliere revalidatieprogramma na een beroerte, leidt tot een extra verbetering in motorische herstel volgens de klinimetrie zoals gehanteerd binnen de in Nederland gebruikte…
The (cost) effectiveness of an intervention on energy balance related behaviours and work engagement
The study aims to develop an intervention to improve workers' energy balance related lifestyle behaviours (EBRB) to prevent overweight and to improve work engagement and subsequently evaluate the intervention developed.