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Investigation of DNA medication passport for antidepressants in primary care.

Investigate the effect of having CYP2C19 and CYP2D6 genotypes at start of antidepressant therapy and it’s cost-effectiveness in the primary care setting.

Treatment of Hemorrhoids: Rubber band ligation Or Sclerotherapy

We want to compare the effectiveness of sclerotherapy and rubberband ligation when it comes to symptoms. We will secondarily consider patient satisfaction, complications and recurrences. We hypothesize that both treatments are equally effective.

Mean arterial pressure alarm compared to hypotension prediction index in preventing intraoperative hypotension

Primary Objective: The performance in preventing intraoperative hypotension of a MAP treatment alarm of 72 mmHg compared to the performance of the HPI alarm. Secondary Objectives: - The correlation between the MAP signal and HPI signal - The…

Complex fractionated atrial electrocardiograms (CFAEs) guided ablation versus pulmonary vein isolation guided ablation in persistent atrial fibrillation, a multicenter randomized trial

to compare the efficacy and safety of complex fractionated atrial electrocardiograms (CFAEs) guided ablation to pulmonary vein isolation based ablation in patients with persistent atrial fibrillation (AF).

TAILOR-AHF: randomized controlled trial investigating a tailored diuretic algorithm in acute heart failure patients

Primary Objective: Investigate if a tailored diuretic algorithm based on Ur-Na has a positive effect on a composite endpoint of mortality, HF events (HFE) and a change in quality of life (QoL) (assessed with the Kansas city…

The safety and cost-effectiveness of discontinuing disease-modifying therapies in stable relapsing-onset multiple sclerosis (DOT-MS): a randomized rater-blinded multicenter trial.

The aim of this study is to identify whether it is possible to safely discontinue treatment in stable RRMS patients who have shown no evidence of active inflammation in the years prior to inclusion in terms of the return of inflammatory disease…

Bifurcation PCI with a hybrid strategy with drug eluting balloons versus a stepwise provisional two-stent strategy. A randomized controlled single-blinded multicentre trial and registry

In this study we will compare a hybrid DEB strategy with a conventional bailout 2-stent strategy (TAP/T-stenting or Culotte) in patients with a bifurcation lesion with sub-optimal side-branch result. The primary endpoint will be the composite…

The role of a nutritional formulation containing caprylic acid and omega 3 fatty acids in promoting skeletal muscle function recovery to damaging exercise in healthy, young volunteers

To assess the impact of a nutritional formulation containing caprylic acid and omega 3 fatty acids on skeletal muscle function recovery from damaging exercise.

fMRI-based Neurofeedback of the basal ganglia in Parkinson*s disease

Primary Objective: Assess the effect of mental imagery with fMRI-neurofeedback-based upregulation of the putamen on motor symptoms of PD Secondary Objective(s): -Assess changes in whole brain activation patterns over the course of the NF training…

Teen Tips: parenting tips for youth well-being

In this study we aim to understand if (personalized) parenting tips strengthen parenting (e.g.: more structure, autonomy support, relatedness, less overparenting) and improve adolescent well-being (e.g.: higher life satisfaction, lower symptoms of…