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Mucoviscidosis and Inflammation, Variability through Exercise and Training: physical exercise program

Primary objective:What is the effect of a 12 weeks physical exercise program on the exercise induced inflammatory response in patients with cystic fibrosis?Secundary objectives:- What are the differences in pre-training basal immune values of…

An Open-Label, Randomized, Phase 3 Trial to Evaluate the Efficacy and Safety of Aztreonam 75 mg Powder and Diluent for Nebuliser Solution (AZLI) versus Tobramycin Nebuliser Solution (TNS) in an Intermittent Aerosolized Antibiotic Regimen, in subjects with Cystic Fibrosis followed by an Open Label, Single Arm Extension

The primary objective of this study is to assess the comparative safety and efficacy ofAztreonam Lysine for Inhalation (AZLI) and Tobramycin Nebuliser Solution (TNS) in adultand pediatric cystic fibrosis (CF) patients aged 6 years or older with…

An exploratory, randomized, double-blind, placebo controlled study to assess the efficacy of multiple doses of omalizumab in cystic fibrosis complicated with allergic bronchopulmonary aspergillosis

A clinical research study to find out if Xolair is safe and has beneficial effects in adolescents (12 years old and above) and adults with cystic fibrosis (CF) and ABPA. All patients entering the study will be taking oral corticosteroids (steroid…

Mucoviscidosis and Inflammation, Variability through Exercise and Training: Maximal exercise test

Primary objective: *What is the effect of an incremental maximal exercise test on inflammation in patients with cystic fibrosis and in healthy people?*Secundary objectives:- What are the differences in basal immune values between HP and CF patients…

COPD: Transition of systemic inflammation into multiorgan pathology (study 3).

To investigate in COPD whether: 1. systemic inflammation and multi-organ disease is more pronounced in more severe COPD2. quadriceps oxidative capacity and fiber type I proportion is reduced, and whether age, sex, smoking, physical activity, GOLD…

The Nanoduct study: a new sweat test system tested

To determine the reliability and feasibility of the Nanoduct sweat test system compared to the gold standard tests QPIT and Macroduct.

Acute and chronic inflammatory responses induced by smoking in individuals being susceptible and non-susceptible for development of COPD: from specific disease phenotyping towards novel made therapy (study 1).

• To define mediators involved in the early induction of COPD in susceptible smokers (and so to define new drug targets)• To develop new biological and clinical markers for the early diagnosis and monitoring of COPD• To characterize the switch to…

Air Trapping and Emphysema Changes During Respiration in Chronic Obstructive Pulmonary Disease.

1. To develop a method that lets us derive measures of air trapping and emphysema from static CT that are independent of inspiration level.In order to achieve this objective we need to:2. study the influence of inspirational level on the extent of…