230 results
To further optimize 7.0 Tesla MRI techniques and to develop new MRI techniques that will enable state-of-the-art clinical and cognitive research leading to improved patient care. Whereas some applications of 7.0 Tesla MRI already show improvements…
The prime objective of the proposed study is to apply treatment modeling for superficial hyperthermia in a well-defined group of patients to investigate the potential of predicted 3-dimensional energy as source for a dose parameter that is…
The objective of this study is to assess the safety, efficacy and pharmacokinetics of 2 doses of LNG, delivered locally by a new intrauterine contraceptive system suitable for use by women 18 to 35 years of age during 3 years and with an extension…
This study aims to identify the relationship between candidate genes such as for instance BDNF, 5-HTTLPR, DAOA, G72, DTNBP1, NRG1 and COMT with cognitive function and emotional- and behavioural traits.
The main objective is to study pregnancy rates after using metabolomic profiling added to the selection of viable embryos by morphology, compared to using only morphology.
The main objective of this specific study is to examine to what extend differences in cognitive functioning between people are due to complex interactions between genes and environment.
The primary objective of the study is to prospectively determine whether fluoropyrimidine-induced toxicity is preventable by dose adjustment prior to start of the first administration based on the polymorphic status of the DPYD*2A polymorphism in…
CAEB071A2206 will assess safety, efficacy and target trough levels for optimal dosing of AEB071 combined with Certican in a CNI-free regimen in de novo renal transplant recipients. This study will combine the investigational drug AEB071 with an…
The aim of the study is to check if the mood-as-input model can give a possible explanation for the persistence behaviour seen in patients with work related upper extremity pain. Because of the fact that the mood-as-input model is only tested in non…
Primary objective:The study has hierarchical co-primary objectives to demonstrate that:- Firstly: dexmedetomidine is at least as effective as sedation with midazolam and daily sedation stops, in maintaining a target depth of sedation in ventilated…
In the light of the aforementioned the current study has three objectives: 1) to study the effectiveness of an in-home self-management intervention to reduce fear of falling, avoidance behavior, catastrophizing about falls in order to prevent…
To determine the improvement in symptoms of constipation in subjects receiving treatment with oxycodone/naloxone prolonged release tablets (OXN) compared to subjects receiving oxycodone prolonged release tablets (OXY) based on the Bowel Function…
Aim of the study is to develop and test a brief intervention for adolescents who have to be treated in the emergency department of a hospital due to excessive alcohol use.
The primary objective is (1) to establish the feasibility of using these neurocognitive tasks in children, and (2) to establish intra-individual variance of task results upon test repetition.The secondary objective is to assess how children have…
To explore the prevalence of testosterone insufficiency in HIV-infected women and the associated sexual problems, fatigue , depression and quality of life.
The current study is designed as a first exploration of this model. The hypothesis is that haloperidol will lead to an amelioration of the *psychotomimetic* effects of the THC-challenge.
We compared three video-assisted laryngoscopes (RangerTM, Glidescope; Storz videolaryngoscopeTM Tuttlingen, Germany and McGrath scopeTM, Aircraft Medical, Edinburgh, UK) in 300 patients undergoing general anaesthesia and aimed to compare: intubation…
Assessing hereditary and aquired determinants of ETP. Evaluating the use of ETP as predictive stand alone test for recurrent DVT and bleeding complications due to anticoagulation therapy in comparisson with the current prediction methods.
To investigate the effectiveness of family meetings on indicated prevention of anxiety and depressive disorders (DSM IV) and symptom levels of primary family caregivers of patients with dementia. To perform an economic evaluation alongside the trial…