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A possible prevention of Obstetric Brachial Plexus Lesion (OBPL)

In this investigation we want to determine if stimulation of the nerve on each side of the neck that leads to the muscles that make the shoudlers shrug is possible in babies. This can possibly prevent a birth lesion of the barchial plexus in the…

Does antenatal allopurinol during perinatal asphyxia reduce post-hypoxic-ischemic reperfusion damage in the newborn? A double blind randomised placebo controlled multicenter trial.

In the present proposal, we aim to answer whether antenatal allopurinol administration does reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia.

Neural plasticity in a Virtual reality-Treadmill combined Intervention for enhancing Mobility and reducing falls in Elderly (V-TIME) with Parkinson's Disease

The primary objective is to study the effects of 12 weeks of treadmill training with virtual reality on neural plasticity in comparison to the effects of treadmill training without virtual reality.Secondary objectives are to investigate the role of…

The effect of cervical spinal cord stimulation on the cerebral blood flow

Effect of SCS on CBF

The effect of oral ingestion of probiotics on the frequency and intensity of migraine attacks

To investigate whether probiotics can reduce incidence and severity of migraine attacks.

Evaluation of Secondary Prevention of Stroke Study in the Outpatient Clinic

The main objective of this study is to determine if the SPC has added benefits in optimising risk factors to prevent recurrent stroke, as compared with secondary prevention performed by the GP.

A randomised multicenter study comparing anterior cervical discectomy with or without interbody fusion and arthroplasty in the treatment of cervical disc herniation.

To show whether Active C disc prosthesis is more effective than anterior discectomy with or without interbody fusion 1 year after surgery. Moreover, the incidence of adjacent disc degeneration will be evaluated 5 years after surgery.

Tryptophan depletion in Parkinson*s disease patients treated with deep brain stimulation of the subthalamic nucleus: effects on mood and motor functions.

Our objective is to assess the effect of TRP depletion on mood and behavior in PD patients treated with STN DBS. By doing, this, we hope to be able to identify risk factors for and mechanisms underlying psychiatric side effects of STN DBS.…

Prevention of Phantom Limb Pain After Transtibial Amputation (PLATA) - Randomized, double-blind, controlled, multi-center trial comparing Optimized intravenous pain control vs Optimized intravenous pain control plus Regional anesthesia

The aim of this study is to test the hypothesis that a combination of optimized intravenous pain therapy and continuous sciatic nerve block decreases the point prevalence of phantom limb pain 12 months after transtibial amputation for peripheral…

Perioperative Transfusion Study (PETS): does a liberal transfusion protocol improve outcome in high-risk cardiovascular patients undergoing non-cardiac surgery?

The primary objective of this study is to assess whether a liberal (6.5 mmol/l) transfusion strategy compared to a restrictive (6.0 mmol/l) transfusion strategy lowers the incidence of major adverse cardiac events (MACE). MACE is defined as a…

Acute peripheral neuropathy in patients treated with oxaliplatin;
Is it possible to decrease the complaints?

Main object Is there a reduction of the acute peripheral neuropathy complaints of patients with advanced or metastatic colorectal cancer due to the infusion of heated oxaliplatin?Does the quality of life of these patients improve?Secondary objectThe…

Prevalence of low bone mineral density in residents of a long-term facility care centre for people with refractory epilepsy, intellectual disability and long-term use of anti-epileptic drugs: a cross-sectional cohort study.

The main objective of this study is to determine the prevalence of low BMD measured with dual-energy X-ray absorptiometry (DEXA) and quantitative ultrasonography (QUS) in Providentia (a residential care facility for persons with refractory epilepsy…

Improving mobility in diabetic patients through resistance training

The objective of this study is to develop a resistance training intervention that improves mobility and quality of life in diabetic patients. It is also our intension to achieve a better understanding of the relation between diabetic neuropathy and…

The efficacy of internet training for migraine self-management

Primary ObjectivesThe primary objectives of this study are to establish:1. The efficacy of internet-delivered SMT for chronic migraine - compared to waitlist control- regarding the post-training improvement of migraine attacks and headache days per…

A Six Month Phase II/III, Randomized, Double-Blind, Placebo-Controlled Clinical Trial to Evaluate the Safety, Tolerability, and Efficacy of Telcagepant (MK-0974) for Prevention of Menstrually Related Migraine in Female Patients with Episodic Migraine

• Test the safety of the research drug, telcagepant (MK-0974)• Test the safety of the research study drug telcagepant (MK-0974) in the prevention of menstrually related migraines. • Compare the effectiveness of the research study drug telcagepant (…

Sitting pressure reduction induced by electrical stimulation during daily life in people with spinal cord injuries .

The main purpose of this study is to evaluate the effects of surface electrical stimulation of the gluteal and hamstring muscles on sitting pressure under the buttocks during daily life (3 hours). A second purpose is to compare the effects of only…

Positioning and electrical stimulation in stroke.

The objective of the study is to assess whether 1) two of the questionnaires used are appropriate for this subgroup of stroke patients and 2) the combination of positioning of the hemiplegic arm with simultaneous application of electrical…

CRYptogenic STroke And underlying AF (CRYSTAL AF )

PRIMARY OBJECTIVETo evaluate the time to first documented event of atrial fibrillation by 6 months continuous rhythm monitoring versus Standard of Care treatment in patients with a recent cryptogenic stroke or TIA without documented history of…

An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…

EMR 200136-532: A three-arm, randomized, double-blind, placebo controlled, multicenter, phase II study to evaluate the efficacy of Vigantol® oil as add-on therapy in subjects with Relapsing-Remitting Multiple Sclerosis receiving treatment with Rebif®

Primary objective: To assess the efficacy of Vigantol oil versus placebo as add-on therapy in subjects with relapsing-RemittingMultiple sclerosis receiving treatment with Rebif.Secondary objective:To assess changes on clinical parametersto assess…