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Assess effect and safety of intra-arterial autologous mesoangioblasts administration to the upper arm of m.3243A>G mutation carriers

This study has been transitioned to CTIS with ID 2024-515129-27-00 check the CTIS register for the current data. In our phase IIa trial we will determine the effect and safety of three MABs administrations in the m. biceps brachii in m.3243A>…

The impact of canola protein processing on postprandial plasma amino acid responses in vivo in young females

The goal of this study is to investigate the most optimal way of canola protein processing on blood plasma amino acid responses in young females.

A Phase 3, Randomized, Double-blind, Placebo-controlled, Parallel, Multicenter Study to Evaluate the Safety and Efficacy of ALXN1720 in Adults with Generalized Myasthenia Gravis.

This study has been transitioned to CTIS with ID 2023-508284-77-00 check the CTIS register for the current data. The purpose of this study is to evaluate the safety and efficacy of ALXN1720 for the treatment of gMG in adults with autoantibodies…

A Randomized, Placebo-Controlled, Multiple Ascending Dose Study Assessing Safety, Tolerability, Pharmacodynamics, Efficacy, and Pharmacokinetics of DYNE-101 Administered to Participants with Myotonic Dystrophy Type 1

This study has been transitioned to CTIS with ID 2023-510353-42-00 check the CTIS register for the current data. The purpose of this first-in-human study is to evaluate the safety, tolerability, efficacy, pharmacokinetics (PK), and pharmacodynamics…

Personalized RehabilitatiOn in severly Fatigued patients with Idiopathic inflammatory myopaThies: a pilot randomized controlled trial

To answer the following questions; (1) What is the estimated effect size of personalized rehabilitation therapy for improving daily functioning in severely fatigued myositis patients, compared to usual care? (2) What are the societal costs of…

In vitro quality assessment of myogenic stem cells in multiple patient groups with confirmed skeletal muscle atrophy to study their potential for autologous stem cell therapy

The study aims to isolate and culture mesoangioblasts from muscle biopsies of two patient groups suffering from skeletal muscle atrophy to assess their potential for autologous muscle stem cell therapy. To relate this potential to the underlying…

A study of the effects of balanced shoulder therapy on shoulder function, local fatigue and pain symptoms in children with FSHD type 1

Primary: To describe shoulder function, local fatigue and pain symptoms around the shoulders in children with FSHD type 1, before and after balanced shoulder therapy. Secondary: To gain insight into the experience of children and parents and the…

The effect of continuous versus intermittent enteral nutrition on metabolic outcomes in critically ill patients.

The primary objective of the CONVEnIENT trial is to investigate the effect of daytime intermittent enteral tube feeding, compared to a standard continuous tube feeding pattern (24-hour/day), on glycaemic control, gastrointestinal function, circadian…

The effectiveness of daily protein supplementation with a plant protein blend vs milk protein to support integrated muscle protein synthesis rates with and without exercise in healthy older individuals.

To assess the effectiveness of daily protein supplementation with either a plant based protein blend or a milk protein on top of a standard diet to stimulate integrated muscle protein synthesis rates in healthy older individuals with and without…

Inspire: INSpiratory muscle training for Patients admitted to ICU and outcomes on Recovery: a pilot randomized controlled trial

This pilot study aims to assess the feasibility of procedures for a future randomised multicentre trial (RCT) on IMT effectiveness after weaning from MV and to gather patient and physiotherapist experiences with IMT.