The goal of this study is to investigate the most optimal way of canola protein processing on blood plasma amino acid responses in young females.
ID
Source
Brief title
Condition
- Gastrointestinal vascular conditions
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Postprandial amino acid concentrations
Secondary outcome
Plasma glucose, insulin, amino acids with their respective peak concentrations
and (i)AUC
Background summary
Muscle tissue consists of proteins. These proteins are built up of small
building blocks: amino acids. By consuming enough protein in our diet, we make
sure that the body is provided with enough amino acids to facilitate muscle
protein building. Providing the growing world population with sufficient
animal-derived protein is a challenge. Plant proteins can be produced on a more
sustainable commercial scale than conventional animal-derived proteins and
therefore, can contribute to feeding our future population. Canola protein is a
protein that is derived from rapeseed. The composition of canola seems to be
comparable to that of other high-quality animal based protein sources. However,
the collection of canola protein from rapeseed occurs in a special way. These
treatment processes might affect canola protein digestion. The goal of this
study is to investigate the most optimal way of canola protein processing on
blood plasma amino acid responses.
Study objective
The goal of this study is to investigate the most optimal way of canola protein
processing on blood plasma amino acid responses in young females.
Study design
A randomized, double-blind, cross-over, intervention trial in which young
females drink 20g of whey protein, native canola protein, heat-treated canola
protein or enzyme-treated canola protein.
Intervention
Drink (20g native canola protein, 20g heat-treated canola protein, 20g
enzyme-treated canola protein, 20g whey protein)
Study burden and risks
The burden and risks associated with participation in this study are moderate.
This study is short in length (4.5 days) with few invasive, but low-risk
measurements.
Insertion of the hand canul can be unpleasant and result in a small hematoma.
However, this makes the 10 blood draws relatively easy. The amount of blood
that is drawn (4 x 110 = 440 ml) is comparable to a blood donation, and should
be replaced within a month.
In total, participants will visit the university five times. Participants are
asked to stay fasted on the test days, which could cause a feeling of hunger.
Drinking water ad libitum is allowed. Participants need to record their food
intake and physical activity in the two days before the test day, this takes 30
minute son average. On these two days, participants should refrain from any
strenuous physical activity and drinking alcohol.
The dexa scan gives insight in participants' body composition and has a minimal
radiation burden. This burden is negligible when comapred to annual background
radiation.
The drinks will consist of 300 ml and will have to be consumed within 5
minutes.
There is no direct benefit for the participants, only their contribution to
scientific knowledge. The participants will gain insight into their body
composition.
Universiteitssingel 50
Maastricht 6229ER
NL
Universiteitssingel 50
Maastricht 6229ER
NL
Listed location countries
Age
Inclusion criteria
- Female sex
- Aged between 18 and 35 y inclusive
- BMI between 18.5 and 30 kg/m2
Exclusion criteria
- Intolerant to milk products
- Mustard allergy
- Participating in a structured (progressive) exercise program
- Smoking regularly
- Diagnosed GI tract disorders or diseases
- Diagnosed musculoskeletal disorders
- Diagnosed metabolic disorders (e.g. diabetes)
- Hypertension (blood pressure above 140/90 mmHg)
- Donated blood 2months prior to testday
- Pregnant
- Using third generation oral contraceptives
- Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories).
- Chronic use of gastric acid suppressing medication
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83369.068.23 |