100 results
The primary objective of the study is to evaluate the long term safety and tolerability of troriluzole as adjunctive therapy in subjects with OCD who have had an inadequate response to standard of care (SOC) treatment for OCD and as defined in the…
We aim to investigate whether sodium oxybate can be used as a novel treatment in psychiatric patients with catatonia. Our primary objective is: To determine if sodium oxybate is effective as a novel treatment in psychiatric patients with catatonia…
The first goal of the current research is to investigate whether EMDR prior to CBT, compared to an active psychological control condition (*supportive counseling*), improves treatment tolerability, adherence, and effectiveness. The second goal is to…
This study has been transitioned to CTIS with ID 2024-517485-42-00 check the CTIS register for the current data. To investigate whether oral esketamine is non-inferior to ECT in achieving treatment response on depression severity in NTRD.
This study has been transitioned to CTIS with ID 2024-513907-15-01 check the CTIS register for the current data. Among patients under treatment for depression, we will select 140 persons with IMD. In this specific group of patients, we will test…
This study has been transitioned to CTIS with ID 2024-517805-10-01 check the CTIS register for the current data. We aim to investigate whether sodium oxybate can be used as a novel treatment in psychiatric patients with catatonia. Our primary…
Establishing efficacy of MFB DBS for TRD by comparing active DBS with sham DBS. Secondary aims are establishing an adverse events profile, establishing effects on quality of life, cost-effectiveness, (neuro)psychological and neuroimaging measures.
This study has been transitioned to CTIS with ID 2024-515198-91-00 check the CTIS register for the current data. To assess the safety, tolerability, biomarker and cognitive efficacy of investigational products in subjects who are known to have an…
Primary Objective: To evaluate the (cost-)effectiveness, feasibility, and acceptability of the culturally and contextually adapted DWM/PM+ stepped-care program among labor migrants in the Netherlands during the COVID-19 pandemic in terms of mental…
ALZ-801 is an oral agent that is being developed as a potential disease modifying treatment for AD. This 78-week Phase 3 study will focus on Early AD subjects who carry the APOE4/4 genotype, and is designed according to current regulatory guidance…
To test whether maximizing inhibitory learning can improve exposure efficacy for those suffering from PTSD.
Primary objective is to compare changes in depression ratings in patients with childhood trauma receiving SAMe with patients receiving a placebo over a 12 week follow-up period. A number of secondary objectives will be investigated: 1. Comparing the…
The primary objective of this trial is to investigate the proposed beneficial effect of raloxifene as compared to placebo when given for twelve weeks in addition to antipsychotic medication to patients with a psychotic disorder. We expect lower…
Primary Objectives:* Change from baseline to week 48 in cognition according to the Alzheimer Disease Assessment Scale-Cognition (ADAS-Cog) compared to placebo.* Changes from baseline to week 48 in ability to perform daily activities according to the…
Primary objective:The primary objective of this study is to evaluate the efficacy of flexibly dosed esketamine nasal spray compared with quetiapine extended-release(XR), both in combination with a continuing selective serotonin reuptake inhibitor (…
The primary objective of this trial in CIAS is to assess the efficacy in improving cognitive impairment using MCCB in patients with schizophrenia treated for 26 weeks with Iclepertin 10mg as compared with placebo.
The study is designed to investigate why withdrawal of off-label antipsychotic drugs for behavioral problems in people with intellectual disability often fails by comparing two blinded groups (withdrawa group versus control group). This has led to…
Primary Objective: To evaluate the feasibility and acceptability of the culturally and contextually adapted WHO*s PM+ intervention for Arabic, Tigrinya and Ukrainian speaking refugee youth living in the Netherlands.Secondary Objective:1. To evaluate…
The primary objective is to study the effect of daily listening for 6 weeks to the Breinbaas hypnosis recordings on self esteem compared to controls. Secondary objective(s) are studying the effect of daily listening to the Breinbaas hypnosis…
This study will assess the effect of combining exercise therapy with CBT 12-16 weeks and explore the mechanisms underlying exercise*s mood- and plasticity-boosting effects. The primary question is whether a higher dose of exercise leads to faster or…