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Investigation of the AcrySof® IQ PanOptix* Presbyopia Correcting IOL Model TFNT00

The objective of this investigation is to describe visual outcomes and assess the safety at 12 months (330 - 420 days) post bilateral implantation of the AcrySof® IQ PanOptix* Presbyopia correcting IOL Model TFNT00.

Clinical Investigation of Visual Function After Bilateral Implantation of Two Presbyopia-Correcting Trifocal IOLs.

Primary Objective:To demonstrate noninferiority of ACRYSOF IQ PanOptix presbyopia-correcting IOL Model TFNT00 to the AT LISA tri IOL Model 839MP in mean photopic binocular uncorrected intermediate (60 cm) visual acuity at Visit 4A.Secondary…

A 12-month, phase IV, randomized, open label, multicenter study to compare efficacy of 0.5 mg ranibizumab PRN versus 2 mg aflibercept bimonthly intravitreal injections on retinal thickness stability till month 6 of treatment and explore functional outcomes up to month 12 in patients with neovascular (wet) age-related macular degeneration (AMD) (CRFB002ADE23, SALT study)

Primary: to compare the treatment effect of ranibizumab PRN (visual acuity loss and/or SD-OCT disease activity guided retreatment) versus aflibercept bimonthly regimen on central retinal thickness stability as measured by mean fluctuations between…

protocol C-10-017: 'Lens Wearing Experience and Biocompatibility of a Marketed MPDS in Silicone Hydrogel and Soft Contact Lens Wearers'

The primary statistical objective of this study is to describe mean differences in corneal staining (type and area), for OPTI-FREE EverMoist Multi-Purpose Disinfecting Solution compared to baseline.

Pilot study to compare straylight perception in pseudophakic subjects with different intraocular lenses

The purpose of this pilot study is to compare the perception of straylight in patients with CE marked multifocal intraocular lenses, measured with 4 different straylight measuring devices..

Comparison of monocular implantation of the Acrysof Toric T2 intraocular lens with a standard monofocal intraocular lens in subjects with cataracts and low corneal astigmatism

- Analyse the effect of the toric T2 intraocular lens on quality of vision, compared to a standard monofocal intraocular lens. - Analyse the satisfaction of patients with their visual acuity with the toric T2 intraocular lens, compared to a standard…

Comparison of the effects of phenylephrine and norepinephrine on hemodynamics and tissue oxygenation in patients undergoing ophthalmic surgery.

Determine whether phenylephrine or norepinephrine has superior haemodynamical effects in ophtalmic surgery

Post market study to evaluate safety and effectiveness of the InnFocus MicroShunt® (MIDI Arrow) in patients with primary open angle glaucoma

The purpose of this study is to collect additional safety and effectiveness of the InnFocus MicroShunt (MIDI Arrow) in subjects suffering from primary open angle glaucoma that are inadequately controlled on maximum tolerated medical therapy with…

Open-label Phase-4 study to examine the change of vision-related quality of life in subjects with diabetic macular edema (DME) during treatment with intravitreal injections of 2 mg aflibercept according to EU label for the first year of treatment.

Primary objectiveTo evaluate the change in quality of life (NEI VFQ 25) in subjects with DME during the first year of treatment with aflibercept according to the EU label for DMESecondary objectives• To assess further the safety and tolerability of…

A Randomized, pilot study, subject-masked comparison of visual function after bilateral implantation of Presbyopia-correcting IOLs

The objective of this study is to prospectively evaluate postoperative visual outcome in a series of patients bilaterally implanted with the AcrySof® IQ ReSTOR® Aspheric +3 D multifocal IOL versus those bilaterally implanted with the LENTIS® Mplus…

Effects of post-operative topical steroid versus intraoperative subconjunctival steroid injection and postoperative miotic on intraocular inflammation following cataract extraction.

Primary Objective: Comparison of incidence of post-cataract extraction ocular inflammation with subconjunctival steroid injection versus traditional eye drops.Secondary Objective: Evaluation of usefulness of physostigmine following cataract surgery.

Long-term follow-up and cross-over of treatment with high-density micropulse laser and half-dose photodynamic therapy in participants of the PLACE trial for chronic central serous chorioretinopathy.

Primary objectives:- To investigate the long-term outcome after successful treatment (no subretinal fluid on OCT) in the PLACE trial.- To investigate whether a cross-over treatment of half-dose PDT to HSML in cCSC patients who either did not respond…

A prospective randomised controlled multicentre trial comparing half-dose photodynamic therapy (PDT) with high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy (CSC).

Primary ObjectiveTo investigate whether half-dose PDT treatment leads to a higher percentage of chronic CSC patients with subretinal fluid on OCT achieving an absence of this subretinal fluid on OCT as compared to HSML treatment.Secondary…

The post-cataract inflammatory reaction with combination therapy of topical steroid and NSAID.

Evaluation of the inflammatory reaction with NSAID and steroid prophylaxis.

A randomized, subject-blinded evaluation of visual function after bilateral implantation of two types of presbyopia-correcting multifocal IOLs

The objective of this study is to prospectively evaluate postoperative visual outcomes in a series of patients bilaterally implanted with the FineVision Micro F IOL versus those bilaterally implanted with the AcrySof® IQ ReSTOR® Aspheric +3 D…

Assessment of Anatomical and Functional Outcomes in Patients Treated with Ocriplasmin for Vitreomacular Traction/Symptomatic Vitreomacular Adhesion (VMT/sVMA)

The objective of this study is to observe the anatomical and functional outcomes of ocriplasmin over a 6-month follow-up period.

A phase IV, long-term, open-label, multicenter extension study to evaluate the safety and tolerability of ranibizumab in subjects with subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD)

Evaluating the long term safety and tolerability of ranibizumab treatment of AMD patients.

A prospective, randomized, double-blind comparison of 5 % against 1.25 % povidone-iodine solution in preoperative antisepsis for strabismus surgery in young children.

To compare the efficacy of 5 % vs. 1.25 % povidone-iodine (PI) as preoperative antiseptic prior to strabismus surgery in children as a prophylaxis of endophthalmitis. Given the low rate of endophthalmitis the conjunctival bacterial flora rate is…

Switching to aflibercept in patients with neovascular AMD not responding to anti-VEGF treatment.

To examine features of treatment response on optical coherence tomography in patients who were switched to aflibercept after non-response to previous intravitreal anti-VEGF treatment.

Evaluation of Clinical Outcomes Following Treatment with Systane® Balance in Dry Eye
Subjects with Lipid Deficiency

The purpose of this research study is to compare Systane Balance Lubricant Eye Drops to Preservative-Free 0.9% Saline as necessary to support Systane Balance reimbursement in France.