63 results
Primary ObjectiveThe primary objective for this study is to compare the clinical efficacy of weekly abatacept in combination with methotrexate to methotrexate alone in achieving Remission, defined as SDAI less than or equal to 3, at Week 24.…
This trial will provide definitive answers with regard to the anti-inflammatory effects of Vitamin D in Crohn*s disease.
Objective of the study is to evaluate efficacy of VZV vaccination in lung transplantation patients, intended to prevent morbidity by VZV infection. Efficacy of vaccination will be measured by means of determining cellular immunity to VZV. Cellular…
Primary objective:To determine whether endotoxin tolerance can be prevented by acetylsalicylic acid prophylaxis or can be reversed by acetylsalicylic acid treatment, expressed as an augmentation of pro-inflammatory cytokine levels during the second…
To investigate whether statin treatment can prevent or delay the development of RA in persons at increased risk of RA.
Primary objective: The primary objective of the study is to determine the effect of concentration/meditation on the innate immune response induced by a lipopolysaccharide (LPS) challenge. Secondary Objective(s): There are two secondary objectives:1…
To improve physical activity levels and physical activity patterns in children with JIA by means of cognitive behavioural training based on the social cognitive theory and the health promotion model, delivered by internet and supported by group…
Primary Objective - To determine if afamelanotide can reduce the severity of PLE related pruritis.Secondary Objectives- To determine if afamelanotide can reduce the frequency of PLE episodes;- To determine if afamelanotide can reduce the duration of…
Objective: To establish the effect of perinatal probiotics on the prevalence of allergic disease at the age of 5 or 6 years.
to identify high risk groups in need for more specific and appropriate guidance. Also to provide adequate counselling and help.
To establish the effect of BCG vaccination in 6 weeks old high-risk infants on the prevalence of asthma and allergic rhinitis at the age of 7 years.
The primary objective of the study is to compare the efficacy of intravenous immunoglobulin product with the efficacy of antibiotic treatment in patients with recurrent respiratory infections and IgG-subclass deficiency and/or selective anti-…
Confirm an association between RA and periodontitis and unravel pathogenic mechanisms underlying this association.
To assess periodontitis-with P. gingivalis in particular- as a pathogenic factor in disease progression of RA.
Objective: Determination of cross-reactivity to a newly developed PPD-derivative (F000175918) in previously PPD-sensitized patients. Hypothesis:Since PPD-derivative F000175918 is categorized as a moderate sensitizer, based on pre-clinical…
The aim of the study is to evaluate the efficacy of sensor augmented pump (SAP) therapy with MiniMed* 640G and SmartGuard* in preventing hypoglycemic events in comparison with continuous subcutaneous insulin infusion (CSII) therapy in type 1…
The main aim of this implementation research is to systematically screen all RA patients of Reade rheumatology and revalidation centre in Amsterdam for their cardiovascular risk profile and if necessary to treat them for cardiovascular risk factors…
The objective of the study is to evaluate a fall prevention program for persons with RA. The primary parameter is to reduce fall incidence in the participants of the fall prevention program.
To assess the prevalence of HIV, hepatitis C and B, and (related) risk behavior among hard drug users in care at Mondriaan carecentre for addiction in Heerlen.
The primary objective of this study is to evaluate the effect of colostrum supplementation on the immune response after intense strenuous exercise.The secondary objective is to study the effect of intense strenuous exercise - and its possible…