64 results
With this prospective registry we aim to evaluate the outcome of patients with a T2-T3 primary melanoma and minimal SN tumor burden, treated by CLND or nodal observation:* The main objective is to determine if T2-T3 melanoma patients with minimal SN…
1. We will recruit 30 probands who meet DSM-IV inclusion criteria for a primary psychotic disorder or mood disorder with psychotic features: schizophrenia, schizoaffective disorder, delusional disorder, bipolar I disorder, psychotic depression, post…
Primary Objective:To characterize a cohort of STXBP1-encephalopathy patients in a standardized, integrative manner, including in-depth clinical profile characterization and EEG recordings. Moreover, for a subgroup of patients, iPSC-derived induced…
The primary objective of this study is to describe and to quantify the change in cardiac mechanoenergetics, expressed by PVL monitoring (reflected by the parameters stroke work, potential energy and pressure-volume area), in patients undergoing…
In-vivo validation of protein makers in minimal invasive skin biopsies from persons with blunt injuries in different time periods.
To assess the efficacy of early mechanical left ventricular unloading and standard of care (inotropes/vasopressors) versus inotropes/vasopressors alone (standard-of-care) in patients with ADHF and signs of cardiogenic shock.
The aim of the present study is identifying CEBA profiles in pwMS and subsequently developing a feasible screening instrument allowing quick identification of CEBA profile and subjective burden of pwMS in clinical practice, providing a suitable…
The aim of this study is to combine acoustic characteristics from spontaneous speech and results from tests at different linguistic levels e.g. the Diagnostic Instrument for Mild Aphasia (DIMA), to determine which aspects in speech are most…
This study has been transitioned to CTIS with ID 2024-512639-58-00 check the CTIS register for the current data. ____________________PRIMARY OBJECTIVESFor Parts 1 and 2: To assess the safety and tolerability of BNT142 at all dose …
We aim to study the rate of developing a biopsy-based diagnosis of high-grade dysplasia (HGD) and EAC in BE patients in a prospective cohort of 204 BE patients at high risk of progression (i.e. after endoscopic removal of visible lesions containing…
We aim to describe and identify distinct daily glucose patters (DGP) in the general population that are related to increased risk of diabetes and diabetes related micro- and macro-vascular complications using the flash sensor technology through the…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
To develop and test new MRI sequences that enable new imaging contrasts and enable depiction of tissue properties that can not be depicted with current techniques.
Compare the effect of three different RBC transfusion strategies* (Standard of care (SoC), SoC+1 and SoC+2**) on heart rate in a population of chronically transfused patients (with on average at least 1 RBC transfusion each 8 weeks as personal…
To compare the effectiveness of a generalist approach (GIT-PD) to specialized psychotherapy for personality disorders (PD) and to predict for which individual patient generalist treatment is not inferior to specialist treatment.
The goal of the present study is to evaluate whether voice or capnometry, alone or in combination with other (non-invasive) biomarkers, can be used to detect emphysema predominant COPD phenotype (>=25% emphysematous lung tissue).
The specific aim of the current study is to investigate the impact of oncological treatment and multiple GA in Rb survivors and Rb risk carriers (8-35 years) on cognitive functioning, psychosocial functioning and HRQoL. Furthermore, psychological…
In this clinical project we aim to fill in gaps in our knowledge on muscle fiber contractility, auto-immunity and myositis: 1) How responsive is human muscle fiber contractility following standard of care immunosuppressive treatment? 2) Is the…
Primary objective:To identify common mutations or other genetic alterations and their potential as therapeutic targets in granulosa cell tumours, by studying human granulosa cell tumour specimens and establishing 3D organoid cell cultures derived…
Abdominal Aortic Aneurysm Sac Healing and Prevention of Endoleaks - A Prospective Multicenter Study.
To evaluate the safety of IMPEDE-FX Embolization Plug and/or IMPEDE-FX RapidFill to fill a AAA sac outside of an EVAR stent graft, and the efficacy of the IMPEDE-FX Embolization Plugs to reduce the volume and/or diameter of the AAA sac and/or the…