82 results
The objective of this trial is to characterize annually the safety and durability data through 10 years in a subset of subjects randomized in the SURTAVI trial.
To study the long-term effects of interferon-α treatment for chronic hepatitis B patients infection.
Original study:The goal of this study is to have a theoretically based understanding of how sub processes of self-concept development emerge in relation to each other. The primary objective is to test a neuroscientific model of self-concept…
The primary aim of the current proposal is to get a better understanding of how CeD risk genes contribute to disease aetiology. To achieve this, we will apply a holistic approach in which we will study the behaviour of immune cells and the…
Aim of this study is to obtain synovial tissue and synovial fluid, from 80 patients with non-septic, inflammatory knee arthritis undergoing routine arthroscopy of the knee and analyze inflammatory factors influencing osteoclast and osteoblast…
Investigate the CGMS results in comparison with an OGTT and one-day self monitoring of blood glucose. Thereby compare the glucose patterns of patients with an impaired glucose tolerance to patient with a normal glucose tolerance and CFRD.
- Assess the influence of air temperature and humidity on cardiovascular, metabolic, and thermic stress during the 4 days marches in Nijmegen in a representative subpopulation.- Identify internal factors (such as body composition, fluit/food intake…
The aim of this study is to compare the sensitivity of chromoendoscopy with Lugol*s solution with conventional white light video endoscopy in diagnosing esophageal dysplasia and cancer in patients with achalasia.
Objective: Evaluation of the supposed correlation between increased serum and urine NGAL levels (> 350 ng/ml) and significant increases in serum creatinine levels in adult ICU patients compared to preclinical levels
Objective: Our goal is to prove that subcuticular sutured wounds will have less discharge than after closure with staples. Secondary outcome is patient satisfaction about wound and wound pain.
We hypothesize that sleep apnea screening, using a combination of an online questionnaire and high resolution overnight oximetry, can safely be applied to exclude sleep apnea with high sensitivity (≥97%) and acceptable specificity (≥60%) in patients…
Progesterone for Breast Development in Trans Women; Assessment of effects and safety -a pilot trial-
To explore the effects on breast development of addition of progesterone to the treatment with estradiol in trans women after vaginoplasty or orchiectomy. Secondary objectives include safety and patient satisfaction, mood, and sleep.
to determine the effect of dietary restriction and the ketogenic diet on the regression of hepatocellular adenoma after 6 months.
Primary Objective: * To evaluate the presence and time of occurrence of a niche in women who underwent a caesarean delivery Secondary Objective(s): * To evaluate changes of niche size and thickness of the residual myometrium over time* To determine…
Assessment of safety and clinical performance of the DREAMS 2nd Generation in de novo coronary artery lesions.
To assess the functional outcomes and cost-effectiveness of K-wire fixation followed by direct mobilization versus open reposition and internal fixation with direct mobilization in adult patients with unstable shaft fractures and fractures with a…
The main objective of this pilot study is to evaluate the effect of motion mitigation with BiPAP or CPAP on tumor motion during the course of radiotherapy in patients with intra-thoracic tumors.
Primary objective: Response to trametinib treatment defined as a tumor volume decreases from baseline of >=20%, monitored by using volumetric MRI analysis. Secondary objectives are: patient reported outcomes of pain and disability and quality…
To prove that omitting drains after mastectomy and flap fixation does not contribute to higher incidence of seroma formation and therefore reducing patient disutility such as seroma aspirations and visits to the outpatient clinic, as well as…
The primary objective is to assess the adaptive T cell response to VIT in HVA patients with underlying ISM (ISM+) after treatment induction (at thirteen weeks) and upon reaching maintenance dose, after seven months, in comparison to the baseline…