59 results
The main objective of this study is to analyse the effect of fetal sex on levels of T and macrophage cell subsets in decidual tissue. Secondary objectives will be to analyse differences in the effect of maternal blood stimulation by fetal leukocytes…
(1) To examine the adherence to the prevention and PCI guidelines and the effects thereof on long term prognosis in PCI patients. (2) To evaluate the effectiveness of the psychosocial screening instrument of the European Society of Cardiology…
Better knowledge and awareness of Late Effects after pediatric HSCT for non-malignant diseases will lead to optimal screening procedures after HSCT that may eventually contribute to reduce transplant-related long term morbidity and mortality and…
Objectives: - To identify and compare motivational behaviour in patients during different phases of cancer treatment. - To test its associations with self-reported fatigue/depression. - To determine to what extent treatment regimen, inflammation,…
To assess toxicity of MRI guided focal salvage high-dose-rate brachytherapy as monotherapy in patients with locally recurrent prostate cancer. As secondary objectives, technical feasibility, quality of life and biochemical free survival (Phoenix…
(I) Investigating the role of the cholinergic system and CBGTC-loop in the pathophysiology of CD, related to both motor and NMS; (II) Finding a biomarker for DBS efficacy in CD, including motor and NMS.
In this study we want to investigate if there is a difference in exposure to losartan and perindopril between younger and elderly patients. Furthermore, the results will enable us to correlate detailed PK data with PD data, which can lead to a more…
In this study the primary objective is to investigate whether activation of TRPV1, TRPA1 and TRPM3 by selective channel agonists induces vasodilation in human dermal arteries. If the primary objective is achieved, the secondary objective is to…
Objective: As we have to integrate information on genetics, immune cells and microbes, a panel of biomaterials (isolated from blood, stool and gastrointestinal mucosal biopsies) will be sampled. From these samples genomic, transcriptomic,…
The main aim is to investigate efficacy of the Therap-i module, in addition to treatment-as-usual (TAU), in decreasing depressive symptoms in patients with MDD, who are unresponsive to protocolized psychological treatment for depression.
The objective is to describe differences in MRI patterns in presymptomatic mutation carriers, patients with mild dementia and controls. We will study whether these patterns are specific depending on the type of dementia (FTD/AD) or mutation (GRN/…
To study the interaction between normal T lymphocytes and Hodgkin tumor cells in an in vitro model.
The primary objective is to establish the relationship between cognitive impairment and cholinergic neurodegeneration in de novo PD patients, by studying cholinergic imaging using [18F]Fluoroethoxy-Benzovesamicol ([18F]FEOBV) PET and…
The development and optimization of new and existing MRI protocols and processing techniques required for advanced anatomical and functional imaging in the research and clinical setting.
To investigate whether treating children with high refractive errors at age one with glasses prevents the development of amblyopia.
The main objective is to assess the effects of environmental pollution risk factors on bone health in-vivo in patients with osteoporotic fractures. We hypothesize that higher levels of heavy metals, particularly lead, are detectable in some patients…
1) Assess the whole genome sequence (WGS) and clinical profile of the MPX families to identify how rare and common genetic variants interact to produce shared versus distinct NDDs and clinical features in individuals, or different combinations of…
Primary Objective: The primary outcome of this study is successful implementation of home-based blood sampling. The success criteria is that 25% or more of the blood assessments are actually performed at home by the patients themselves using a self-…
In this study we will assess the applicability of a digital intake in the Dutch colorectal cancer screening program in participants with a positive FIT who are referred for colonoscopy.
The overall goal of this study is to accelerate the development of new therapies for DM1 by validating new clinical assessments for measuring disease status and collecting data and biological samples to help understand disease progression and…