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A Phase 2, Multicenter, Multi Arm, Study to Evaluate MK-1308A (Coformulated
quavonlimab (MK-1308)/pembrolizumab) Versus Other Treatments in
Participants with Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient
(dMMR) Stage IV Colorectal Cancer: (MK-1308A-008)

This study has been transitioned to CTIS with ID 2022-502100-70-00 check the CTIS register for the current data. The aim of this research is:1. To test the safety of MK-1308A, MK-4280A, MK-7684A and MK 4830 + pembrolizumab against pembrolizumab as…

A PHASE Ib/II, OPEN-LABEL, MULTICENTER STUDY EVALUATING THE SAFETY, ACTIVITY, AND PHARMACOKINETICS OF GDC-6036 IN COMBINATION WITH OTHER ANTI-CANCER THERAPIES IN PATIENTS WITH PREVIOUSLY UNTREATED ADVANCED OR METASTATIC NON-SMALL CELL LUNG CANCER WITH A KRAS G12C MUTATION

This study has been transitioned to CTIS with ID 2023-507171-22-00 check the CTIS register for the current data. The purpose of this study is to evaluate the safety, pharmacokinetics, and activity of GDC-6036 combined with other anti-cancer…

A Randomized Clinical Trial Investigating Olaparib, Durvalumab (MEDI4736) and UV1 as Maintenance Therapy in BRCAwt Patients with Recurrent Ovarian Cancer

This study has been transitioned to CTIS with ID 2024-516327-14-00 check the CTIS register for the current data. This study is evaluating the preliminary efficacy of UV1-olaparib-durvalumab combination against both olaparib as monotherapy and…

Effect of cryo- and compression therapy after Total Knee and Unicompartmental Arthroplasty, A Randomised Controlled Trial*

Primary objective:Investigating the effect of the use of cryo- and compression therapy during the first 6 postoperative weeks after surgery (TKA en UKA) on the perceived pain in rest at 6 weeks postoperative.Secundary objectives:Investigating the…

Promoting Resilience in Youth through Mindfulness mEditation

The aim of this study is to determine if mindfulness-based early intervention reduces internalizing symptoms in help-seeking youth and prevents their development into (serious) psychiatric illnesses. In addition we will examine putative changes in…

A PHASE II, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO EVALUATE THE SAFETY, EFFICACY, AND PHARMACODYNAMICS OF 52 WEEKS OF TREATMENT WITH BASMISANIL IN PARTICIPANTS AGED 2 TO 14 YEARS OLD WITH DUP15Q SYNDROME FOLLOWED BY A 2-YEAR OPTIONAL OPEN-LABEL EXTENSION

Part 1:To evaluate the effects of 52 weeks of treatment with basmisanil on core symptom domains of Dup15q syndrome (language and social skills) and dailyfunctioning. Part 2:• To evaluate the tolerability and safety of up to 3 years of treatment with…

*A personalized lifestyle approach for abdominal pain in Irritable Bowel Syndrome and inflammatory bowel disease: a proof of concept study using Experience Sampling Method (ESM) and a digital food diary (Traqq).'

Apart from its use to provide insight in IBS disease courses and in clinical research, ESM can provide patients with feedback about individual triggers of their symptoms, and thereby function as part of a personalized therapeutic strategy. This is…

The Vold-study: The effect of a 12-week self-composed vegan diet with or without concurrent resistance exercise on thigh muscle volume in older adults

Primary: To assess the effects of a 12-week self-composed vegan diet in comparison to an omnivorous diet on thigh muscle volume (TMV) in community-dwelling older adults. And to assess the effect of a 12-week self-composed vegan diet combined with…

Re-Evaluation of the Corvia Atrial Shunt Device in a Precision Medicine Trial to Determine Efficacy
in Mildly Reduced or Preserved EF Heart Failure

The primary objective of this clinical trial is to further evaluate the clinical efficacy of the Corvia Atrial Shunt in symptomatic heart failure patients with a left ventricular ejection fraction (LVEF) >= 40%, and elevated left sided…

Magnesium Supplementation as a Strategy to Reduce Serum Calcification Propensity and Vascular Stiffness in People with Type 2 Diabetes.

To investigate the effect of daily intake of 350 milligrams of magnesium citrate oral supplementation over a period of six months on calciprotein particle maturation time (T50) in serum, a measure of calcification propensity, and on vascular…

Personalized Risk-Adapted Therapy in Post-Pubertal Patients with Newly Diagnosed Medulloblastoma (PersoMed-I)

The hypothesis is that personalised and risk-adapted treatment will improve outcome and reduce toxicity in post-pubertal patients with medulloblastoma.A further hypothesis is that clinical, magnetic resonance imaging (MRI) and voxel-based…

A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter Study of Upifitamab Rilsodotin (XMT-1536) as Post-Platinum Maintenance Therapy for Participants with Recurrent, Platinum-Sensitive Ovarian Cancer (UP-NEXT)

In this study, we look at how safe the new medicinal product XMT-1536 is for the treatment of ovarian cancer and how well it works. We compare the effect of XMT-1536 with the effect of a placebo. A placebo is a product without the active ingredient…

Active vitamin D for secondary hyperparathyroidism after bariatric surgery: a multicenter randomized controlled trial.

This study has been transitioned to CTIS with ID 2023-510312-40-00 check the CTIS register for the current data. Main objective- to investigate the effect of alfacalcidol on the treatment of secondary hyperparathyroidism in patients after RYGB…

Appropriate use of Blood Cultures in the emergency department through machine learning: a randomized controlled trial.

The aim of this study is to see whether we can safely use blood cultures more efficiently. By using a prediction model, we support the clinical decision to analyse a blood culture. If the chance that this culture yields a positive result is very…

A phase 1, randomized, placebo-controlled, double-blind, single center, multiple-dose, parallel trial evaluating the impact of apraglutide on gastric emptying of liquids in healthy subjects

The purpose of this study is to see if the study compound, apraglutide, has any effect on the gastric emptying of liquids in healthy subjects. Gastric emptying is the normal way in which food passes through the body, when the contents of the stomach…

Affective touch; reducing pain in Parkinson patients study 2

To determine whether CT-optimal touch can reduce pain experience in patients with Parkinson.

The effect of acute stress on executive functioning and decision-making in healthy military personnel.

To study if acute stress has a significant effect on executive functioning scores in healthy military personnel.

Understanding overweight and obesity: The end of average

This project therefore adopts an urgently needed comprehensive individualized approach. We characterize each participant in a large sample of individuals varying in bodyweight by their own baseline comprehensive profile, including person…

Preoperative Intermittent Fasting versus Carbohydrate Loading to Reduce Insulin Resistance: a Randomised Controlled Trial

The main objective is to investigate whether preoperative TRF improves perioperative insulin resistance compared to CHL and standard preoperative fasting.Our secondary objective is to investigate the feasibility of preoperative TRF in terms of…

Early PReserved SPONtaneous breathing activity in mechanically ventilated patients with acute respiratory distress syndrome - The PReSPON Randomized Controlled Trial

To evaluate the efficacy and safety of preserved spontaneous breathing activity in the early phase of moderate to severe ARDS.