To compare the plasma amino acid responses after the digestion of whey vs different ratios whey and collagen protein following a single bout of exercise in healthy young men.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Eiwitvertering
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Plasma amino acid response
Secondary outcome
Plasma insulin-, and glucose responses
Background summary
PProtein ingestion stimulates muscle protein synthesis and augments the muscle
protein synthetic response to a single exercise session. In support, protein
supplementation has been shown to augment the gains in muscle mass and strength
following resistance exercise training. The force generated by contracting
muscle is transferred through a network of connective tissue proteins towards
the bone. Consequently, remodeling of skeletal muscle connective tissue
represents an essential component of skeletal muscle adaptation to exercise.
The anabolic effect of a protein supplement is mainly determined by the plasma
amino acid response after ingestion. Although whey protein is considered the
preferred protein source to maximize myofibrillar protein synthesis rates, it
contains insufficient glycine and proline to support the post-exercise increase
in connective tissue protein synthesis rates. In contrast, collagen protein is
rich in glycine and proline and has, therefore, been proposed as a preferred
protein source to support connective tissue remodelling. Hence, the combined
ingestion of whey plus collagen protein increase may therefore be preferred to
stimulate both myofibrillar and collagen protein synthesis rates in skeletal
muscle tissue. However, the ratio of collagen vs whey protein within one drink
for an optimal post-prandial rise in amino acid concentrations remains to be
determined.
Study objective
To compare the plasma amino acid responses after the digestion of whey vs
different ratios whey and collagen protein following a single bout of exercise
in healthy young men.
Study design
Randomized, double-blinded, crossed-over experiment
Intervention
Following a single bout of resistance exercise subjects will be randomly
assigned to consume one of the following test beverages per test day
- a test beverage of 600 mL containing 30 g whey protein in water,
- a test beverage of 600 mL containing 25 g whey + 5 g collagen protein in
water,
- a test beverage of 600 mL containing 20 g whey + 10 g collagen protein in
water,
- a test beverage of 600 mL containing 15 g whey + 15 g collagen protein in
water,
After ingestion, blood samples will be taken at regular intervals during a 6
hour resting period.
Study burden and risks
The risks involved in participating in this experiment are minimal. Insertion
of a catheter in a vein is comparable to a normal blood draw and the only risk
is a small local hematoma.
universiteitssingel 50
Maastricht 6200 MD
NL
universiteitssingel 50
Maastricht 6200 MD
NL
Listed location countries
Age
Inclusion criteria
- Males
- Aged between 18-35 years
- Healthy, recreationally active (participating in recreational sports
activities <3 times per week)
- BMI < 30 kg/m2
- No physical limitations (i.e. able to perform all activities associated with
daily living in an independent manner).
Exclusion criteria
- Female
- Allergies to milk proteins
- Musculoskeletal disorders
- Use of any medications known to affect protein metabolism (i.e.
corticosteroids, non-steroidal anti-inflammatories, or prescribed acne
medications).
- Participation in any structured regular exercise program
- Chronic use of gastric acid suppressing medication oranti-coagulants
- Unstable weight over the last three months
- Pathologies of the gastrointestinal tract
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74226.068.20 |