To investigate the short-term effect of a vegan diet on daily muscle fractional synthesis rates in comparison to an omnivorous diet in community-dwelling older adults.
ID
Source
Brief title
Condition
- Other condition
- Appetite and general nutritional disorders
- Muscle disorders
Synonym
Health condition
glucose- en lipidenmetabolismestoornissen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter includes the difference in muscle fractional
synthesis rates (FSR; %/day) between the vegan diet and omnivorous diet.
Secondary outcome
Secondary study parameters include the difference in satiety, blood pressure,
plasma blood glucose, insulin and lipid profile (HDL; LDL; cholesterol;
triglycerides) between the vegan and the omnivorous diet.
Background summary
A major cause of global environmental change is food production, with animal
based food products having the greatest impact on the environment. Therefore,
consumers are increasingly encouraged to consume more plant-based foods and
lower their consumption of foods from animal origin. However, the consequences
of such a transition on muscle mass still remains to be explored. This is of
particular importance in the older population, where sarcopenia is highly
prevalent. Sarcopenia is referred to as the age-related loss of lean mass and
physical functioning, and begins approximately in the fifth decade of life.
Adequate dietary intake, specifically protein intake, is a well-known strategy
in counteracting sarcopenia in older adults. Plant-based foods are currently
considered to be inferior to animal-based foods in their protein quality,
suggesting that a diet fully consisting of plant-based foods (vegan diet) may
be suboptimal for the preservation of muscle mass in older adults. Current
evidence regarding the anabolic properties of vegan diets is scarce.
Study objective
To investigate the short-term effect of a vegan diet on daily muscle fractional
synthesis rates in comparison to an omnivorous diet in community-dwelling older
adults.
Study design
A randomized controlled cross-over study.
Intervention
The intervention will be a fully controlled vegan diet with a duration of 10
days and will be compared to a fully controlled omnivorous diet with the same
duration. Participants will be randomized to the order in which they consume
the diets.
Study burden and risks
The risks of the study are minimal and acceptable. All products in the diets
are commercially available. The short duration of the vegan diet excludes the
possible risks of fractures, muscle wasting and vitamin B12 deficiency. Methods
used to explore the effects have been widely used in other studies and will be
performed according to SOPs. No side effects have been previously observed
following the deuterated water protocol that will be used in this study.
Venepuncture and muscle biopsies will be performed by the trained research
physician and may cause some discomfort, but further risks are minor.
Stippeneng 2
Wageningen 6708 PD
NL
Stippeneng 2
Wageningen 6708 PD
NL
Listed location countries
Age
Inclusion criteria
Aged 65-79 years
Community-dwelling
Body Mass Index (BMI) 20-35 kg/m2
Exclusion criteria
- Following a vegetarian or vegan diet during the six months prior to the study;
- Following a diet that affects protein intake during the six months prior to
the study;
- >=5% of body weight loss during three months before the start of the study;
- Participating in a structured exercise training program in the past 3 months;
- Being diagnosed with one of the following: diabetes; renal disease;
neurological or neuromuscular disorders; serious cardiovascular diseases;
cancer; chronic obstructive lung disease (COPD);
- Chronic use of medication that affects muscle function, e.g. corticosteroids,
metformin, insulin;
- The use of the following medicines: acenocoumarol (sintrom); phenprocoumon
(marcoumar); dabigatran (pradaxa); apixaban (eliquis); rivaroxaban (xarelto);
clopidogrel (plavix); combination of acetylsalicylic acid or carbasalate
calcium (ascal) with dipyridamole.
- Allergic or intolerant to any product included in the diets;
- Not willing to stop nutritional supplements, with the exception of
supplements on medical advice, and vitamin D;
- Not willing or afraid to give blood or undergo a muscle biopsy during the
study;
- Unwilling to eat a vegan and an omnivorous diet for ten days each;
- Not vaccinated for COVID-*19;
- Currently a research subject in another trial or participated in a clinical
trial during 3 months before the start of the measurement period;
- Not being able to understand Dutch;
- Not having a general physician.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL76916.028.21 |
| OMON | NL-OMON26953 |