The main objective of the current project is to assess the effect of long-term jump training combined with collagen supplementation on bone mineral density in elite cyclists.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
botgezondheid
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Lumbar spine bone mineral density.
Secondary outcome
Blood parameters of bone turnover: Procollagen type I N propeptide (P1NP),
carboxy-terminal crosslinking telopeptide of type I collagen (CTX-I).
Countermovement jumps will assess the effect of the intervention on jump height
as a marker of lower body power.
Background summary
Bone health is a critical factor for athletes as bones provide the levers for
muscles to move the joints, and strong bones decrease the risk of bone
fractures. Particularly cyclist can benefit from exercise and nutrition
interventions to stimulate bone health, as this population is characterized by
an impaired bone mineral density. Jumping exercise has been identified as a
feasible and effective exercise intervention to stimulate collagen synthesis
and increase bone mineral density. However, there is considerable debate on the
optimal volume and frequency of jumping exercise to maximize bone collagen
synthesis. Furthermore, preliminary evidence suggests that collagen
supplementation may also stimulate bone collagen synthesis. It is currently
unknown whether collagen supplementation can augment the increase in bone
collagen synthesis after jumping exercise.
There is evidence to suggests that cycling exercise training has a negative
effect on bone metabolism. Hence, it may me of particular interest for elite
cyclists to know whether jumping exercise and collagen supplementation can
counteract the deleterious effects of cycling exercise training on bone tissue.
Study objective
The main objective of the current project is to assess the effect of long-term
jump training combined with collagen supplementation on bone mineral density in
elite cyclists.
Study design
Open label, randomized intervention study. The study involves 18 weeks of jump
exercise training with pre- and post-measurements of bone mineral density.
Intervention
All participants will be randomly assigned to the intervention or
no-intervention group. Intervention group will receive:
Exercise training: During the 18-week exercise training program participants
will complete five weekly exercise sessions.
Collagen supplementation: The collagen supplements (15 g) will be ingested ~1 h
before each training session.
Study burden and risks
Participants will visit our lab 2 times (duration ~30 - 60 min).
In total 2 blood samples (20 mL/sample) will be drawn (via vena punction). The
discomfort of this procedure is transient and is comparable to having an
injection by a needle, or donating blood.
*Participants will have to perform non-exhaustive rope skipping exercise, which
is meant to stimulate bone synthesis.
The collagen product is a commercially available, with food-grade food
ingredients that are safe in the amounts consumed in this study.
BMD and body composition will be assessed twice by DXA. The measurement is
painless, non-invasive and involves only low radiation exposure (<10 *Sv).
Altogether, it can be concluded that the burden and risks associated with this
study are limited.
Heyendaalseweg 141
Nijmegen 6525 AJ
NL
Heyendaalseweg 141
Nijmegen 6525 AJ
NL
Listed location countries
Age
Inclusion criteria
* Elite cyclists status
* Age *16 and *35 years.
* Willing to give blood samples
* Willing to comply with study procedures
Exclusion criteria
* Blood donation during the study period
* Severe allergy to nuts or intolerance to gluten, as supplements are being
produced in factory that may have used nuts or gluten previously
* Use of antibiotics in the past month
* Medical condition that can interfere with the study outcome (i.e.
cardiovascular disease, pulmonary disease, rheumatoid arthritis, orthopaedic
disorders, renal disease, liver disease, diabetes mellitus, inflammatory
disease, cognitive impairment, and thyroid or parathyroid disease))
* Use of medications known to interfere with selected outcome measures (i.e.
corticosteroids, , statins, fenofibrate, beta-blocker)
* (Chronic) injuries of the locomotor system that can interfere with the
intervention.
* Current participation in another biomedical research study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL78314.096.21 |