To develop a computer*based algorithm for quantitative LUS analysis that accurately estimates lung aeration. A chest CT-scan will be used as the reference test.
ID
Source
Brief title
Condition
- Respiratory disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Lung aeration of the 12 lung regions evaluated through LUS.
Secondary outcome
* Lung aeration as measured by CT
* Estimation of lung aeration by a conventional visual LUS scoring
* Other LUS findings (e.g., pleural line abnormalities, lung pulse, lung
sliding abolition, pleural effusion)
* Indications for chest CT scanning
* Mechanical ventilator settings during the LUS examination and chest CT-scan
* Ventilator parameters
* Hemodynamical parameters
Background summary
Monitoring of lung aeration is crucial in Intensive Care patients, especially
in invasively ventilated patients. The gold standard for measuring lung
aeration is chest Computed Tomography (CT). Unfortunately, a chest CT scan is
difficult to obtain in invasively ventilated Intensive Care Unit (ICU) patients
and cannot be repeated frequently. Lung Ultrasound (LUS) as a point*of*care
imaging tool is increasingly used in the Intensive Care Unit setting. Lung
aeration by LUS is presently evaluated through semi*quantitative visual scores.
Automated quantification could improve accuracy of lung aeration estimations.
Study objective
To develop a computer*based algorithm for quantitative LUS analysis that
accurately estimates lung aeration. A chest CT-scan will be used as the
reference test.
Study design
This is a single*center, prospective observational study.
Study burden and risks
Participants will not directly benefit from participation, but burden is
absent. Of note, in this study chest CT-scans are never performed for the
purpose of this study * they are clinically indicated and follow the standard
protocol for chest CT-scans in critically ill patients. In addition, LUS is a
non*invasive procedure without additional risks, and the skin markers used in
this study are safe and without burden for patients.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
* Admitted to the intensive care unit for adults of the Academic Medical Center in Amsterdam, The Netherlands
* Receiving invasive ventilation
* Having a chest CT-scan performed on a clinical indication
Exclusion criteria
* Age < 18 years
* Lung Ultrasound (LUS) not feasible (e.g., severe chest trauma, extensive burns on the thorax, open wounds on the thorax)
* No written informed consent of the patient or his/her formal representative
* Reported allergy to skin tape, necessary to attach the skin markers to identify fields at chest CT scans
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL64089.018.17 |
| OMON | NL-OMON29300 |