Magnetic Resonance Imaging in healthy volunteers, for the improvement of radiotherapy for patients with thoracic-abdominal cancer

In radiotherapy, the aim is to deliver a high dose to the target while
minimizing the dose to the surrounding healthy tissue. Underdosage of the
target may compromise treatment, whereas irradiation of healthy tissues can
lead to severe toxicity with a detrimental impact on quality of life.
For radiotherapy treatment planning, data on expected uncertainties and
variations in anatomy and motion are needed. Even though eventually patient
data are required, availability of patient data is often limited. Therefore,
using data from healthy volunteers is highly beneficial. To obtain these data,
MRI is the preferred modality, as this technique (which uses non-ionizing
radiation) does not pose any risk to healthy volunteers.

In this study, we gather information on (changes in) organ shape and motion in
the abdomen and thorax in volunteers. This information will be used to improve
the radiotherapy treatment planning for patients with abdominal-thoracic
tumors.
Primary objective: Visualize and quantify motion, displacement and deformation
of organs and anatomical landmarks in the abdomen and thorax, such as heart,
lungs, diaphragm, liver, stomach, spleen, kidneys, pancreas, and duodenum.
Secondary objective: Establish suitable MRI scanning parameters to visualize
motion, displacement and deformation of certain organs.

This is an observational study (MR imaging of changes and motion in
abdominal-thoracic anatomy in healthy volunteers).

(Burden) MRI session = 2.5 hours (three 30-minute scans, with time to eat/drink
in between); minimal restrictive measures apply, such as eating and/or no
eating prior to imaging.
(Risks) MR imaging uses non-ionizing radiation; no risks associated with MR
imaging.
(Benefit) No benefit.
(Group relatedness) Not applicable.