Primary: To further characterize a cohort of older patients with bipolar disorder, including clinical features, cognition, social functioning, need of care, family history and inflammation markers.Secondary: To investigate the effects of aging on…
ID
Source
Brief title
Condition
- Manic and bipolar mood disorders and disturbances
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
exploration of relation between pro-inflammatory cytokines (IL-6) and stage of
bipolar disorder
Secondary outcome
none
Background summary
Despite the decreasing prevalence of bipolar disorder with age, the absolute
number of bipolar elderly will increase substantially in the coming years due
to ageing of the total population. To date research on characteristics, course
and need of care is largely lacking, so to tailor psychiatric treatment
programs for older patients with bipolar disorder research is is warranted. In
2012 we investigated 101 bipolar elderly patients attending an out-patient
clinic by clinical interviewing to establish their psychopathology, social and
cognitive functioning, quality of living and unmet needs in care.
Following our older bipolar patients over time will provide data on the effects
of aging on their cognitive functioning, physical health and the course of
their psychiatric symptoms. Our dynamic cohort will increase our statistical
power to study older bipolar patients on different aspects and provide unique
longitudinal data on these patients.
Next to questionnaires for clinical phenotyping we want to set up a rich
biobank.
Study objective
Primary: To further characterize a cohort of older patients with bipolar
disorder, including clinical features, cognition, social functioning, need of
care, family history and inflammation markers.
Secondary: To investigate the effects of aging on cognitive functioning,
physical health and the course of psychiatric symptoms in older patients with
bipolar disorder in a naturalistic longitudinal cohort.
Study design
Patients participating in DOBi, a dynamic cohort of older patients with bipolar
disorder using questionnaires for clinical phenothyping will be requested to
particpate.
Study burden and risks
There will be a one time blood draw of 18 ml. There is no risk as this will be
combined with blood draw for regular care in most cases.
Amstelveenseweg 589
Amsterdam 1081JC
NL
Amstelveenseweg 589
Amsterdam 1081JC
NL
Listed location countries
Age
Inclusion criteria
Patients will be included in the study only if the diagnostic procedure (described next) ascertained a diagnosis of bipolar 1 disorder (DSM-IV-TR: 296.00- .06, 296.40-.46, 296.50-.56, 296.60-.66, 296.7), bipolar 2 disorder (DSM-IV-TR: 296.89), or bipolar disorder NOS (DSM-IV-TR: 296.80).
Exclusion criteria
Patients unable to provide written informed consent due to inability to communicate in Dutch or English, mental retardation (defined as IQ below 70), poor cognition (Mini Mental State Examination (MMSE) below 18) or clinical diagnosis of dementia, or a highly unstable psychiatric condition (e.g. current compulsory admission) were excluded.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL62873.029.17 |