The objective of this study is to investigate the intra-individual change in AMH levels over several years in female RA patients.
ID
Source
Brief title
Condition
- Autoimmune disorders
- Sexual function and fertility disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Serum anti-Müllerian hormone (AMH) levels
Secondary outcome
not applicable
Background summary
Fertility is reduced in women with rheumatoid arthritis (RA). Furthermore,
female RA patients reach menopause at a younger age. Therefore, we hypothesize
that the ovarian reserve, as measured by serum anti-Müllerian hormone (AMH)
levels, is lower in female RA patients than in controls from the general
population. Furthermore, we hypothesize that the decline in serum AMH levels in
female RA patients is related to RA disease characteristics and the use of
methotrexate.
Study objective
The objective of this study is to investigate the intra-individual change in
AMH levels over several years in female RA patients.
Study design
Observational longitudinal study
Study burden and risks
Patients will be visited at home once. Serum samples will be drawn (4 mL per
patient) and a short questionnaire with questions about the menstrual period
and medication use will be completed.
Wytemaweg 80
Rotterdam 3015 CN
NL
Wytemaweg 80
Rotterdam 3015 CN
NL
Listed location countries
Age
Inclusion criteria
Women who participated in the PARA study (2002-2010):
- a diagnosis of RA according to the ACR 1987 criteria
- actively trying to conceive or pregnant at the time of enrolment in the PARA study
- a good understanding of the Dutch language
Available serum from preconceptional visits or the visit 26 weeks post partum in the PARA study.
Exclusion criteria
Women who did not participate in the PARA study
Women who are currently living outside the Netherlands or Belgium
Women for whom no serum samples are available from the preconceptional visit or the visit 26 weeks after delivery during the PARA study
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL52975.078.15 |