We aim to assess the effect of sleeping with open or closed curtains on sleep quality and sleep loss and circadian phase of melatonin.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
sleep loss
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Sleep timing and sleep quantity from sleep diaries (subjective) and actimetry
(objective; sub-group only).
Secondary outcome
Sleep quality from subjective sleep diaries, and light exposure assessed from
sleep diaries. In addition, secondary objective parameter in this study in a
sub-sample of 20 participants is melatonin concentration in saliva. The start
of the rhythm will be measured: dim light melatonin onset (DLMO). A shift in
DLMO is interpreted as a shift in the endogenous circadian pacemaker.
Background summary
Sleep is a basic human need and essential for good health, quality of life and
performing well during the day. The timing of sleep is regulated by a
homeostatic process (sleep pressure increasing with time awake) and circadian
process. The latter is synchronised (entrained) to the 24-hour light-dark cycle
by light. The relationship between external (social) and internal (biological)
time is called phase of entrainment. People that differ in this trait have
different chronotypes. The distribution of chronotypes is (almost) bell-shaped,
with few extreme chronotypes at both ends. Chronotype is assessed via the
Munich Chronotype Questionnaire (MCTQ) based on calculating the mid-point of
sleep on free days (MSF) and workdays (MSW), with the MSF being corrected for
sleep deficit accumulated across the workweek (MSF sleep corrected, MSFsc).
Social jetlag is quantified as the difference between MSF and MSW, and is a
marker for circadian rhythm disruption and chronic physiological stress, which
is positively correlated with smoking and body mass index (BMI). The modern
24/7-society ignores that sleep timing is individual, affecting sleep quality
and quantity, leading to sleep deprivation and directly impacting recuperation
and long-term health. About three quarters of the general population rely on
their alarm clocks on workdays, which especially concerns later chronotypes
with early work schedules. From controlled laboratory studies, there is ample
evidence showing the detrimental effects of sleep deprivation on health and
performance, with consequences that would be catastrophic in real life -
especially in e.g. shift-work occupations. These studies also show that the
thresholds for the effects of sleep deprivation are hard to identify by an
individual, meaning we need solutions that provide individuals with ways to
better acknowledge their state of sleep loss. One solution to this problem
would be to delay sleep on workdays until it matches sleep on free days,
meaning to fully taking account of an individual*s chronotype. Such strategy
would require delaying working hours, an approach of obviously little success
for plenty social reasons and constraints. The alternative solution is to
advance sleep onset on workdays using controlled light exposure, so as to allow
for longer sleep duration and to decrease the workweek daily sleep loss. We
hypothesise that a continuous earlier sleep onset across weeks and months on
workdays will result in an advance of sleep onset also on free days.
Study objective
We aim to assess the effect of sleeping with open or closed curtains on sleep
quality and sleep loss and circadian phase of melatonin.
Study design
The study takes 30 days in total. During the first 14 days we ask participants
to only complete the sleep diary (less then 5 minutes). The 16 following days
participants will be asked to follow the protocol: if sleeping usually with
curtains closed then sleep with curtains open & if usually sleeping with
curtains open then sleep with curtains closed. Once per week participants also
complete the online version of the the MCTQ (e.g. every Sunday). In a sub-group
of 20 participants we will assess endogenous circadian phase of melatonin from
saliva samples and daily rest/activity profiles using actigraphy.
Intervention
For 16 days sleeping with open curtains (if usually closed) or sleeping with
closed curtains (if usually open).
Study burden and risks
We do not expect any adverse effect from participating in our study.
Nijenborgh 7
Groningen 9747 AG
NL
Nijenborgh 7
Groningen 9747 AG
NL
Listed location countries
Age
Inclusion criteria
Healthy men and women between 18 and 45 years of age
Chronotype (MSFsc) of greater than 4 (meaning a sleep mid point at 04:00 a.m.)
Social jetlag = difference between mid-sleep on workdays and days off of
minimum 2 hours
Habitual sleep duration on free days between 6 and 10 hours
Bed partners agree to the study protocol
Written informed consent
Exclusion criteria
Sleep disorders, e.g. sleep apnoea, narcolepsy, restless legs, primary insomnia
Mood disorder; because of the possibility of depressive mood as co morbidity in late chronotypes we will set the criterion for exclusion based on depressive mood on a BDI-II rating equal to or higher than 16 (indicating severe dysphoric or depressed mood)
Two or more time zones crossed 1 month before study participation
Shift-work during 5 years prior to participation
Recent eye surgery (last year), glaucoma or other eye disease
History of chronic diseases, and/or use of chronic medication for 3 months or longer before study participation
Alcohol or drug problems (based on answers to the General Questionnaire)
The use of sleep and photosensitizing medication
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL45405.042.13 |