Is recurrent miscarriage an independent risk factor for an increased cardiovascular risk?
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
- Abortions and stillbirth
- Vascular hypertensive disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Cardiovascular risk factors, prevalence of chronic hypertension, metabolic
syndrome and cardiovascular diseases are the main endpoints.
Secondary outcome
na
Background summary
Recurrent miscarriages is commonly defined as three or more consecutive
miscarriages prior to the 20th week. It is a common problem affecting 1 to 2%
of all fertile couples and is a highly heterogeneous condition. An underlying
cause may be identified in about 25-50% of cases.
There is increasing evidence that women with hypertension or preeclampsia
during pregnancy are at increased of cardiovascular diseases later in life
compared to women with normotensive pregnancies. As suggested by previous
studies, placenta insufficiency syndrome maybe a first sign of cardiovascular
disease, which could also be true for recurrent miscarriages.
Identifying women with risk factors for cardiovascular diseases as early as
possible makes it possible for them to benefit from preventive interventions
Study objective
Is recurrent miscarriage an independent risk factor for an increased
cardiovascular risk?
Study design
A retrospective case control study in cardiovascular risk factors
Study burden and risks
Participation in this trial is not expected to be a burden or bare any risk.
Albinusdreef 2
Leiden 2333ZA
NL
Albinusdreef 2
Leiden 2333ZA
NL
Listed location countries
Age
Inclusion criteria
Recurrent miscarriages ( >2 subsequently)
Age >18
Exclusion criteria
Pregnant or lactating women within the last 3 months.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
Register | ID |
---|---|
CCMO | NL40524.058.12 |
Other | NTR nr volgt nog |