What is the effect of the use of a maltitol sweetened chewing gum compared to a gum base and no gum in during a 28 days on the composition of the supragingival plaque microbiome in healthy non dental students *18 years old?
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
Microbiologie van de supragingivale tandplaque
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
2 Supra gingival plaque samples
Secondary outcome
Food questionnaire
Background summary
This metgenomic study is based on the Marsh*s theory ( Marsh et al 2006, BMC
oral health). This theory consist in considering that the bacteria of dental
plaque belong to a dynamic equilibrium where various factors can be
deleterious. Indeed environment( diet health status) can let or not some
pathogenic bacteria colonizing dental plaque. The equilibrium can move form a
**healthy state** to a **sick state**.
Sugar alcohols, a class of polyols, are commonly added to foods because of
their lower calorific content compared to sugars. Maltitol, sorbitol, xylitol,
erythritol are often used as sweetner in chewing gum because they are not
broken down by bacteria in the mouth or metabolized to acids, and thus do not
contribute to tooth decay. Importantly, polyol sugars promote tooth
mineralization by increasing the flow of saliva. Xylitol and sorbitol have been
demonstrated in vivo and in vitro to inhibit growth of a number of cariogenic
bacterial species, including mutans streptococci, most prominently
Streptococcus mutans and Streptococcus sobrinus. The exact mechanism of action
of xylitol on mutans streptococci (MS) is not fully known but habitual xylitol
consumption, at high enough doses reduces counts of MS, apparently making
plaque and mutans streptococci less adhesive to teeth. Loesche et al showed
that consumption of 5*7 g of xylitol in chewing gum reduced MS in both plaque
and saliva but not counts of S. sanguis. Very little is actually known about
the effects of the polyole sugars on the oral microbiota. This study aims to
establish the effects of frequent consumption of chewing gum (sweetened with
maltitol or the use of gum base) during 28 days on the oral microbiome
composition, and to relate to effects to microbial risk factors for gingivitis
and caries. Also, the prolonged effects of chewing gum (sweetened with maltitol
or the use of gum base) consumtion are examined after 2 weeks. The study can
contribute to effective dosage of gum consumption and improve our understanding
on the level of the dental plaque ecosystem.
Study objective
What is the effect of the use of a maltitol sweetened chewing gum compared to a
gum base and no gum in during a 28 days on the composition of the supragingival
plaque microbiome in healthy non dental students *18 years old?
Study design
This is a parallel single- blind (examiner), randomized clinical trial.
Intervention
Intervention= maltitol sweetened chewing gum. 3x daily 2 maltitol gums
Placebo= gum base. 3 x daily 1 gum
Control= no gum
Study burden and risks
Neither immediate nor long- range physical risks are involved.
Gustav Maherlaan 3004
Amsterdam 1081 LA
NL
Gustav Maherlaan 3004
Amsterdam 1081 LA
NL
Listed location countries
Age
Inclusion criteria
- Male and female - Age *18 years - Classified as systemically healthy, assessed by medical questionnaire - Non-smokers - Minimum of 20 natural teeth: at least 5 evaluable teeth in each quadrant - DPSI 0-3- - With moderate gingivitis (30-60% BOMP) - No partial dentures - No orthodontic banding - No oral lesions - Subjects who do not use a interdental device at home. - No use of antibiotics 60 days before baseline - No pregnancy/breast feeding - No participation in clinical trials 30 days before baseline - No consumer of > 3 sugar free chewing gums a day - Willing and able to give written informed consent - No medication except for birth control pills
Exclusion criteria
- Anyone presenting with a probing depth * 5mm with bleeding on probing and attachment loss * 2 mm - Overt dental caries - Usage of any interdental device as part of regular daily oral care - Smokers - DPSI 3+-4 - Removable (partial) dentures - Crowns, bridges and implant supported restorations - Removable night guard - Oral and/or peri-oral piercings - Apparent oral lesions (aphthous ulcers excluded) - Presence of orthodontic banding (except for lingual retention wire) - Dental student or dental professional - Participation in a clinical study within the previous 30 days ;General health and use of medication:
- Self-reported pregnancy or breastfeeding - Use of antibiotics during the last 2 months - Need of antibiotic prophylaxis prior to dental treatment - Use of anti-inflammatory drugs on a regular basis - Evidence of any systemic disease or compromised health condition - Adverse medical history or long-term medication - Prescribed medication (except for birthcontrol pills)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL45518.018.13 |
| OMON | NL-OMON27321 |
| OMON | NL-OMON28925 |