To determine the effect of protein status on food preferences and intake.
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
obesitas
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Our main outcome measurement is the difference in protein intake (g) during the
2-day ad libitum-phase following the two interventions.
Secondary outcome
Our secondary outome measurements are:
• The difference in energy intake during the 2-day ad libitum-phase following
the two interventions;
• The difference in subjective appetite ratings during the low protein diet and
the high protein diet;
• The difference between the two interventions on different aspects of food
liking and wanting measured with an Food Preference Questionnaire;
• The difference in systolic blood pressure following the low protein diet and
the high protein diet.
Background summary
It has been posed that protein intake is tightly regulated in the human body.
It has been shown that when subjects have eaten high-protein meals, a
significantly greater reduction is seen in liking for high-protein food than
for high-carbohydrate foods. In our previous research, we did not observe this
effect within one meal. Animal and human studies suggest that energy and
macronutrient balance are regulated over a longer period of time.
Study objective
To determine the effect of protein status on food preferences and intake.
Study design
The study will consist of two 14-day fully controlled dietary interventions
that involve consumption of individualized, isoenergetic menus providing either
0.5 g protein/kg BW/day (low protein diet), or 2.0 g protein/kg BW/day (high
protein diet), using a randomized crossover design. The interventions will be
followed by a 2-day ad libitum-phase, where protein intake (g) will be
measured. Both interventions will be preceded by 2 days on which subjects eat a
normal protein diet (1.0 g protein/kg BW/day). The interventions will be
separated by a minimum of 1 week washout, and during this period, subjects will
be asked to consume their usual diets.
Intervention
The study will consist of two 14-day fully controlled dietary interventions
that involve consumption of individualized, isoenergetic menus providing either
0.5 g protein /kg BW/day (low protein diet), or 2.0 g protein /kg BW/day (high
protein diet),
Study burden and risks
Nature and extent of the burden and risks associated with participation,
benefit and group relatedness: The study is non-therapeutic to the
participants. The risk associated with participation is negligible and the
burden can be considered as moderate. No invasive measurements are present.
P.O. Box 8129
6700 EV Wageningen
NL
P.O. Box 8129
6700 EV Wageningen
NL
Listed location countries
Age
Inclusion criteria
Section 4.2 from the research proposal
• Age: 18-35 years
• BMI: 20.0 - 25.0 kg/m2
• Healthy (as judged by the participant)
Exclusion criteria
Section 4.3 from the research proposal
• Restraint eating (men: score > 2.25; women: score > 2.80)
• Lack of appetite
• Having difficulties with swallowing/eating
• Usage of a energy restricted diet during the last two months
• Weight loss or weight gain of 5 kg or more during the last two months
• Stomach or bowel diseases
• Kidney disorders
• Diabetes, thyroid disease, other endocrine disorders
• Prevalent cardiovascular disease
• A systolic blood pressure of >=160 mmHg at screening
• Usage of daily medication other than birth control pills
• For women: pregnant or lactating
• Being a vegetarian
• Being allergic/intolerant for products under study
• Having participated in studies that have used the FoodPreferenceQuestionnaire (LFPQ): *RiceTime*, *LunchTime*, *Smaak-Geur*, SenSation, and *ProStudy*, or current participation in other research from the division of human nutrition (WUR)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL32871.081.10 |